PLA2G4A - phospholipase A2 group IVA Gene

Also Known as GURDP; cPLA2; PLA2G4; cPLA2-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5321

About PLA2G4A

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,828,949-186,988,981 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 6.0), adrenal (RPKM 5.6) and 24 other tissues.

Summary

This gene encodes a member of the cytosolic Phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane Phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular Hormones that regulate hemodynamics, inflammatory responses, and Other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular CA(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

PLA2G4A Products (2)

mRNA	Protein	Name
NM_001311193.2	NP_001298122.2	cytosolic phospholipase A2 isoform 2
NM_024420.3	NP_077734.2	cytosolic phospholipase A2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables O-acyltransferase activity	IDA IDA: Inferred from direct assay	7794891	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	9430701	GOA
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	7794891	GOA
enables calcium-dependent phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	18451993	GOA
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	9665851	GOA
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	12672805	GOA
enables ceramide 1-phosphate binding	IDA IDA: Inferred from direct assay	17472963	GOA
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	12672805	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	12672805	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	12672805	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	12672805	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	8702602	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	7794891	GOA
involved in leukotriene biosynthetic process	IMP IMP: Inferred from mutant phenotype	18451993	GOA
involved in monoacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	7794891	GOA
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	16617059	GOA
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	7794891	GOA
involved in phosphatidylglycerol catabolic process	IDA IDA: Inferred from direct assay	9425121	GOA
involved in positive regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	18451993	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	27642067	GOA
involved in prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	18451993	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11375391	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11375391	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	11375391	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G4A Protein Structure

PLA2_B

0
200
400
600
749 a.a.

Protein Preferred Names	Protein Names
cytosolic phospholipase A2	calcium-dependent phospholipid-binding protein

PLA2G4A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87025	Phospho-Cytosolic Phospholipase A2 (S505) Antibody (YA6718)	WB, Dot Blot	Human, Mouse

Related Diseases

Diseases	Alias
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets	Cytosolic Phospholipase-A2 Alpha Deficiency Associated Bleeding Disorder GURDP Deficiency Of Phospholipase A2, Group Iva Phospholipase A2, Group Iva, Deficiency Of Pla2g4a-Related Platelet Dysfunction Platelet Dysfunction Due To Cytosolic Phospholipase-A2 Alpha Deficiency
Cryptogenic Multifocal Ulcerous Stenosing Enteritis	Cmuse Cmuse - [Cryptogenic Multifocal Ulcerous Stenosing Enteritis]
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Primary Hypertrophic Osteoarthropathy	Pachydermoperiostosis Syndrome Osteoarthropathy, Primary Hypertrophic Pachydermoperiostosis Of Nail Idiopathic Hypertrophic Osteoarthropathy Pho
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.86%	Unkown
HY-RS10626	PLA2G4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17434	Pla2g4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23889	Pla2g4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLA2G4A	VGNC	VGNC:44626
Rattus norvegicus	PLA2G4A	RGD	RGD:67366
Mus musculus	PLA2G4A	MGD	MGI:1195256
Felis catus	PLA2G4A	VGNC	VGNC:68881
Macaca mulatta	PLA2G4A	VGNC	VGNC:76156
Bos taurus	PLA2G4A	VGNC	VGNC:32960
Others	PLA2G4A	NCBI