Plcb1 - phospholipase C beta 1 Gene

Also Known as PLC'1; Phosphb; PLCbeta1; RATPHOSPHB

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24654

Summary

Enables calcium ion binding activity; identical protein binding activity; and phosphatidylinositol Phospholipase C activity. Involved in several processes, including cellular response to glyceraldehyde; cellular response to ionomycin; and learning or memory. Located in cytosol; membrane; and nucleus. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; and myelodysplastic syndrome. Orthologous to human PLCB1 (Phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcb1 Products (1)

mRNA Protein Name
NM_001077641.2 NP_001071109.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
11377826 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16763092 RGD
enables phosphatidylinositol phospholipase C activity IDA
IDA: Inferred from direct assay
15159145 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11161216 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fluoride IDA
IDA: Inferred from direct assay
11377826 RGD
involved in cellular response to glyceraldehyde IDA
IDA: Inferred from direct assay
11377826 RGD
involved in cellular response to ionomycin IDA
IDA: Inferred from direct assay
11377826 RGD
involved in cellular response to vasopressin IDA
IDA: Inferred from direct assay
11377826 RGD
involved in inositol trisphosphate metabolic process IDA
IDA: Inferred from direct assay
8387502 RGD
involved in learning IEP
IEP: Inferred from expression pattern
15159145 RGD
involved in memory IEP
IEP: Inferred from expression pattern
15159145 RGD
involved in phosphatidylinositol catabolic process IDA
IDA: Inferred from direct assay
8387502 RGD
involved in phosphatidylinositol metabolic process IEP
IEP: Inferred from expression pattern
12786971 RGD
involved in response to monosaccharide IDA
IDA: Inferred from direct assay
11377826 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
11377826 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

  • PLC-154

  • PLC-I

  • PLC-beta-1

  • Phospholipase C-beta1

  • phosphoinositide phospholipase C

  • phosphoinositide phospholipase C-beta-1

  • phospholipase C, beta 1 (phosphoinositide-specific)

  • phospholipase C-I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10652 PLCB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21691 Plcb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28209 Plcb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcb1 NCBI NCBI:23236