Oas2 - 2'-5' oligoadenylate synthetase 2 Gene

Also Known as Oasl11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 246728

Summary

Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in defense response to virus; regulation of lactation; and type I interferon signaling pathway. Acts upstream of or within RNA catabolic process; interleukin-27-mediated signaling pathway; and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in embryo. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]

Oas2 Products (2)

mRNA Protein Name
NM_001347448.1 NP_001334377.1 2'-5'-oligoadenylate synthase 2 isoform 1
NM_145227.3 NP_660262.2 2'-5'-oligoadenylate synthase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 2'-5'-oligoadenylate synthetase activity IDA
IDA: Inferred from direct assay
12396720 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
12396720 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within RNA catabolic process IDA
IDA: Inferred from direct assay
15865429 MGI
involved in defense response to virus IDA
IDA: Inferred from direct assay
29117179 MGI
involved in interleukin-27-mediated signaling pathway IEP
IEP: Inferred from expression pattern
32270034 MGI
involved in regulation of lactation IMP
IMP: Inferred from mutant phenotype
29117179 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
involved in type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
29117179 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2'-5'-oligoadenylate synthase 2

  • (2-5')oligo(A) synthase 2

  • 2',5'-oligoadenylate synthetase-like 11

  • 2,5-oligoadenylate synthetase-like 11

  • 2-5A synthase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09728 OAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20316 Oas2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26824 Oas2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oas2 NCBI NCBI:4939