Prnp - prion protein Gene

Also Known as PrP; Prn

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24686

Summary

Enables several functions, including ATP-dependent protein binding activity; chaperone binding activity; and lamin binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in cytoplasm; plasma membrane; and postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (Prion Protein). [provided by Alliance of Genome Resources, Apr 2022]

Prnp Products (2)

mRNA Protein Name
NM_001395658.1 NP_001382587.1 major prion protein precursor
NM_012631.3 NP_036763.1 major prion protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent protein binding IPI
IPI: Inferred from physical interaction
16774738 RGD
enables lamin binding IPI
IPI: Inferred from physical interaction
21277044 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
16774738 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
16750514 RGD
enables type 5 metabotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
24012003 RGD
Biological Process GO Annotation Evidence References Source
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
17156386 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16766127 RGD
involved in negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
23386614 RGD
involved in negative regulation of long-term synaptic potentiation IDA
IDA: Inferred from direct assay
21593310 RGD
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23386614 RGD
involved in response to cadmium ion IDA
IDA: Inferred from direct assay
16148034 RGD
involved in response to copper ion IDA
IDA: Inferred from direct assay
16148034 RGD
Cellular Component GO Annotation Evidence References Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
22820466 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

major prion protein

  • prion protein, PrP

  • prion protein, structural

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11188 PRNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18367 Prnp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24846 Prnp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992294 Anti-PRNP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prnp NCBI NCBI:5621