Tac1 - tachykinin, precursor 1 Gene

Also Known as TAC; PPTA3; Ppt5fl; RATPPTA3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24806

Summary

Enables substance P receptor binding activity. Involved in several processes, including learning or memory; positive regulation of secretion; and positive regulation of synaptic transmission. Located in extracellular space and plasma membrane. Used to study central sleep apnea and pulmonary hypertension. Biomarker of colitis and respiratory syncytial virus infectious disease. Orthologous to human TAC1 (tachykinin precursor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tac1 Products (4)

mRNA Protein Name
NM_001124768.1 NP_001118240.1 protachykinin-1 isoform b precursor
NM_001124769.1 NP_001118241.1 protachykinin-1 isoform c precursor
NM_001124770.1 NP_001118242.1 protachykinin-1 isoform d precursor
NM_012666.2 NP_036798.1 protachykinin-1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables substance P receptor binding IDA
IDA: Inferred from direct assay
18634782 RGD
Biological Process GO Annotation Evidence References Source
involved in associative learning IDA
IDA: Inferred from direct assay
19071162 RGD
involved in long-term memory IDA
IDA: Inferred from direct assay
19071162 RGD
involved in negative regulation of heart rate IDA
IDA: Inferred from direct assay
2471579 RGD
involved in positive regulation of action potential IDA
IDA: Inferred from direct assay
18158108 RGD
involved in positive regulation of acute inflammatory response IDA
IDA: Inferred from direct assay
19222484 RGD
involved in positive regulation of corticosterone secretion IDA
IDA: Inferred from direct assay
8391371 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
18634782 RGD
involved in positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
17435548 RGD
involved in positive regulation of lymphocyte proliferation IMP
IMP: Inferred from mutant phenotype
18621988 RGD
involved in positive regulation of ossification IDA
IDA: Inferred from direct assay
17204323 RGD
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
17435548 RGD
involved in positive regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
19261870 RGD
involved in positive regulation of synaptic transmission, cholinergic IDA
IDA: Inferred from direct assay
17949415 RGD
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
18938661 RGD
involved in response to hormone IMP
IMP: Inferred from mutant phenotype
18195491 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18337316 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18337316 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
6167867 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protachykinin-1

  • PPT

  • Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma)

  • tachykinin 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14136 TAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18639 Tac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25124 Tac1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tac1 NCBI NCBI:6863