Tpm1 - tropomyosin 1 Gene

Also Known as Tma2; Tmsa; Alpha-tm

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24851

Summary

This gene is a member of the tropomyosin family and encodes a protein that heterodimerizes with a beta subunit, binding actin in both muscle and nonmuscle cells. In both smooth and striated muscle cells, it plays a role in calcium dependent-regulation of muscle contraction. In nonmuscle cells, it stabilizes Cytoskeleton actin filaments. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Tpm1 Products (12)

mRNA Protein Name
NM_001034068.1 NP_001029240.1 tropomyosin alpha-1 chain isoform a
NM_001034069.1 NP_001029241.1 tropomyosin alpha-1 chain isoform Tpm1.6cy
NM_001034070.1 NP_001029242.1 tropomyosin alpha-1 chain isoform Tpm1.7cy
NM_001034071.1 NP_001029243.1 tropomyosin alpha-1 chain isoform Tpm1.3sm
NM_001034072.1 NP_001029244.1 tropomyosin alpha-1 chain isoform Tpm1.10br
NM_001034073.1 NP_001029245.1 tropomyosin alpha-1 chain isoform Tpm1.8cy
NM_001034074.1 NP_001029246.1 tropomyosin alpha-1 chain isoform Tpm1.9cy
NM_001034075.1 NP_001029247.1 tropomyosin alpha-1 chain isoform Tpm1.13
NM_001301336.1 NP_001288265.1 tropomyosin alpha-1 chain isoform Tpm1.1st
NM_001301342.1 NP_001288271.1 tropomyosin alpha-1 chain isoform Tpm1.2st
NM_001301736.1 NP_001288665.1 tropomyosin alpha-1 chain isoform Tpm1.12br
NM_019131.2 NP_062004.1 tropomyosin alpha-1 chain isoform Tpm1.11br

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
19041430 RGD
enables actin binding IMP
IMP: Inferred from mutant phenotype
14640678 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
7568216 RGD
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
11329279 RGD
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
15475586 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7568216 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16420482 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15779917 RGD
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
7568216 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
7568216 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament capping IDA
IDA: Inferred from direct assay
15779917 RGD
involved in cardiac muscle contraction IDA
IDA: Inferred from direct assay
14551059 RGD
involved in muscle filament sliding IDA
IDA: Inferred from direct assay
11136687 RGD
involved in negative regulation of cell migration IGI
IGI: Inferred from genetic interaction
15897890 RGD
involved in positive regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
11136687 RGD
involved in positive regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
11329279 RGD
involved in positive regulation of cell adhesion IGI
IGI: Inferred from genetic interaction
17721995 RGD
involved in positive regulation of stress fiber assembly IGI
IGI: Inferred from genetic interaction
15897890 RGD
involved in regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
19041430 RGD
involved in ruffle organization IGI
IGI: Inferred from genetic interaction
15897890 RGD
involved in wound healing IGI
IGI: Inferred from genetic interaction
17721995 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
7568216 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15823548 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin alpha-1 chain

  • hepatoma alpha tropomyosin

  • smooth muscle alpha-tropomyosin

  • striated muscle alpha-tropomyosin

  • tropomyosin 1, alpha

  • tropomyosin 3 alpha

  • tropomyosin-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14936 TPM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17596 Tpm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24056 Tpm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm1 NCBI NCBI:7168