Tsc2 - TSC complex subunit 2 Gene

Also Known as Rc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24855

Summary

Enables GTPase activator activity and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of signal transduction; and regulation of neuron projection development. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including caveola; growth cone; and neuronal cell body. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study autism spectrum disorder; hepatic angiomyolipoma; and renal cell carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Tsc2 Products (1)

mRNA Protein Name
NM_012680.3 NP_036812.2 tuberin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
12869586 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9045618 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15093748 RGD
Biological Process GO Annotation Evidence Références Source
acts upstream of or within cell projection organization IGI
IGI: Inferred from genetic interaction
16286931 RGD
acts upstream of or within cell projection organization IMP
IMP: Inferred from mutant phenotype
16286931 RGD
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20530489 RGD
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
14612383 RGD
involved in negative regulation of TOR signaling IDA
IDA: Inferred from direct assay
12869586 RGD
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
12511557 RGD
involved in negative regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
18794346 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17376623 RGD
acts upstream of or within negative regulation of cell size IMP
IMP: Inferred from mutant phenotype
16286931 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
14612383 RGD
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20813961 RGD
involved in negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
18056446 RGD
involved in negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
24599401 RGD
involved in negative regulation of pinocytosis IMP
IMP: Inferred from mutant phenotype
9045618 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18056446 RGD
involved in negative regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11553313 RGD
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
20813961 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
16595860 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
20530489 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17376623 RGD
involved in protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
20813961 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
24889507 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
24889507 RGD
involved in social behavior IMP
IMP: Inferred from mutant phenotype
20927644 RGD
Cellular Component GO Annotation Evidence Références Source
located in caveola IDA
IDA: Inferred from direct assay
15093748 RGD
located in cell projection IDA
IDA: Inferred from direct assay
17376623 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15525761 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24889507 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24889507 RGD
located in growth cone IDA
IDA: Inferred from direct assay
14559897 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15525761 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14559897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tuberin

  • renal carcinoma

  • tuberous sclerosis 2 homolog protein

  • tuberous sclerosis 2 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-150229 306-N16B 99.27% Unkown
HY-134904 RMC-6272 Inhibitor 97.42% Unkown
HY-RS15132 TSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23540 Tsc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134922 NS1-IN-1 Inhibitor / Unkown
HY-155475 mTORC1-IN-2 Inhibitor / Unkown
HY-RS17096 Tsc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tsc2 NCBI NCBI:7249