Prkcb - protein kinase C, beta Gene

Also Known as Pkcb; Prkcb1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25023

About Prkcb

Primary_assembly 1: 176,832,226-177,163,536 forward strand.mRatBN7.2:CM026974.1

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 25 phenotypes. Biased expression in Brain (RPKM 562.1), Spleen (RPKM 51.2) and 6 other tissues.

Summary

Enables protein kinase C activity. Involved in several processes, including dibenzo-p-dioxin metabolic process; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb Products (2)

mRNA Protein Name
NM_012713.4 NP_036845.3 protein kinase C beta type isoform 1
NM_001172305.1 NP_001165776.1 protein kinase C beta type isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7537734 RGD
Biological Process GO Annotation Evidence References Source
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
16797713 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
11714718 RGD
involved in positive regulation of odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
15763930 RGD
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
15647254 RGD
involved in regulation of growth IMP
IMP: Inferred from mutant phenotype
3345563 RGD
involved in response to angiotensin IDA
IDA: Inferred from direct assay
11507002 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16997974 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15030177 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
10206343 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
15647254 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
17272350 RGD
located in centrosome IDA
IDA: Inferred from direct assay
14594954 RGD
located in cytosol IDA
IDA: Inferred from direct assay
11507002 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcb Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

STKc_cPKC_beta

STKc_cPKC_beta: cd05616 (340 - 662)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

protein kinase C beta type

  • PKC-beta

  • protein kinase C beta I

  • protein kinase C beta II

  • protein kinase C, beta 1

Prkcb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Prkcb P68403 Ptpra Mus musculus P18052
Protein Kinase Assay
7537734
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcb NCBI NCBI:5579