Htr1b - 5-hydroxytryptamine receptor 1B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25075

Summary

Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Located in plasma membrane. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Htr1b Products (1)

mRNA Protein Name
NM_022225.2 NP_071561.1 5-hydroxytryptamine receptor 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
15328035 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
16546225 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels EXP
EXP: Inferred from Experiment
17067296 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
17067296 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
15328035 RGD
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
16839853 RGD
involved in feeding behavior IMP
IMP: Inferred from mutant phenotype
12373419 RGD
involved in negative regulation of gamma-aminobutyric acid secretion IDA
IDA: Inferred from direct assay
30217553 RGD
involved in negative regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17229091 RGD
involved in negative regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
17392733 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
17067296 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17067296 RGD
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
16885935 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
17067296 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
17067296 RGD
involved in response to cocaine IDA
IDA: Inferred from direct assay
17509084 RGD
involved in response to ethanol IMP
IMP: Inferred from mutant phenotype
16212943 RGD
involved in response to mineralocorticoid IEP
IEP: Inferred from expression pattern
11882579 RGD
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held EXP
EXP: Inferred from Experiment
17067296 RGD
is active in calyx of Held IDA
IDA: Inferred from direct assay
17067296 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 1B

  • 5-HT-1B

  • 5-HT1B serotonin receptor

  • 5-hydroxytryptamine (serotonin ) receptor 1B

  • 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

  • serotonin (5-hydroxytryptamine (5HT)) receptor type 1B

  • serotonin receptor 1B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS06461 HTR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20424 Htr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26933 Htr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr1b NCBI NCBI:3351