Rgn - regucalcin Gene

Also Known as Rc; GNL; Reguc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25106

Summary

Enables calcium ion binding activity and gluconolactonase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of hydrolase activity; and positive regulation of lipid biosynthetic process. Located in cytosol and nucleus. Used to study familial hyperlipidemia. Biomarker of hepatocellular carcinoma. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Apr 2022]

Rgn Products (1)

mRNA Protein Name
NM_031546.2 NP_113734.1 regucalcin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
699201 RGD
enables gluconolactonase activity IDA
IDA: Inferred from direct assay
16585534 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
16786169 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
8794449 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8794449 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
7759556 RGD
involved in negative regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
11500948 RGD
involved in negative regulation of DNA catabolic process IDA
IDA: Inferred from direct assay
2001740 RGD
involved in negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
11510494 RGD
involved in negative regulation of RNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
12397604 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15806309 RGD
involved in negative regulation of bone development IDA
IDA: Inferred from direct assay
12239582 RGD
involved in negative regulation of bone development IMP
IMP: Inferred from mutant phenotype
11129957 RGD
involved in negative regulation of calcium-dependent ATPase activity IMP
IMP: Inferred from mutant phenotype
10861851 RGD
involved in negative regulation of cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
1656206 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
16142398 RGD
involved in negative regulation of flagellated sperm motility IDA
IDA: Inferred from direct assay
23615721 RGD
involved in negative regulation of macromolecule biosynthetic process IDA
IDA: Inferred from direct assay
2280766 RGD
involved in negative regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12686401 RGD
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
11455566 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
9827702 RGD
involved in positive regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
16786169 RGD
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
10797571 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
11693188 RGD
involved in positive regulation of fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
16817230 RGD
involved in positive regulation of glucose metabolic process IDA
IDA: Inferred from direct assay
16817230 RGD
involved in positive regulation of phosphatase activity IMP
IMP: Inferred from mutant phenotype
9671264 RGD
involved in positive regulation of proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
1513338 RGD
involved in positive regulation of superoxide dismutase activity IDA
IDA: Inferred from direct assay
15375603 RGD
involved in positive regulation of triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
16817230 RGD
involved in regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
16786169 RGD
involved in spermatogenesis IDA
IDA: Inferred from direct assay
23615721 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regucalcin

  • SMP-30

  • gluconolactonase

  • regucalcin (senescence marker protein-30)

  • senescence marker protein 30

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176537 RGN6024 99.28% Unkown
HY-RS11896 RGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19568 Rgn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26065 Rgn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgn NCBI NCBI:9104