Drd5 - dopamine receptor D5 Gene

Also Known as D1B

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25195

About Drd5

Primary_assembly 14: 72,489,347-72,490,774 reverse strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 190 orthologues, 35 paralogues and is associated with 12 phenotypes.

Summary

Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating Dopamine Receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (Dopamine Receptor D5). [provided by Alliance of Genome Resources, Apr 2022]

Drd5 Products (1)

mRNA	Protein	Name
NM_012768.2	NP_036900.2	D(1B) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	12623966	RGD
enables dopamine neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	1831904	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19465068	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	1831904	RGD
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	1831904	RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	16914681	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	16914681	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	16914681	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	17142305	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	16175554	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	12623966	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16175554	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	21749912	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16914681	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16914681	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21749912	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	21749912	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
D(1B) dopamine receptor	d(5) dopamine receptor dopamine D5 receptor dopamine receptor 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04006	DRD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04007	Drd5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04008	Drd5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd5	NCBI	NCBI:1816