DRD5 - dopamine receptor D5 Gene

Also Known as DBDR; DRD1B; DRD1L2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1816

About DRD5

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:9,781,634-9,784,009 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues, 25 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes the D5 subtype of the Dopamine Receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

DRD5 Products (1)

mRNA	Protein	Name
NM_000798.5	NP_000789.1	D(1B) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dopamine binding	IDA IDA: Inferred from direct assay	1826762	GOA
enables dopamine neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	1826762	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11500503	GOA
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	1826762	GOA
involved in cellular response to catecholamine stimulus	IDA IDA: Inferred from direct assay	18403039	GOA
involved in negative regulation of NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	16352863	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	16352863	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary membrane	IDA IDA: Inferred from direct assay	20531939	GOA
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA
located in non-motile cilium	IDA IDA: Inferred from direct assay	20531939	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10531415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRD5 Protein Structure

7tm_1

0
100
200
300
400
477 a.a.

Protein Preferred Names	Protein Names
D(1B) dopamine receptor	D1beta dopamine receptor d(5) dopamine receptor dopamine D5 receptor dopamine receptor D1B

DRD5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DRD5	P21918	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	DRD5	P21918	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DRD5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89951	D5DR Antibody (YA9295)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Specific Developmental Disorder
Substance Dependence
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Migraine Without Aura	Common Migraine Migraine With Or Without Aura, Susceptibility To Migraine Without Aura, Susceptibility To Acute Migraine Without Aura
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Blepharospasm
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Conduct Disorder
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Blepharospasm, Benign Essential	Benign Essential Blepharospasm Blepharospasm, Primary Benign BEB Blepharospasm Primary Blepharospasm Essential Blepharospasm Spasm Of Eyelids Blepharospasm, Benign Essential, Susceptibility To Obsolete: Benign Essential Blepharospasm Eyelid Twitching
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Focal Dystonia	Dystonia, Focal, Task-Specific
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04006	DRD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04007	Drd5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04008	Drd5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DRD5	VGNC	VGNC:40096
Felis catus	DRD5	VGNC	VGNC:61629
Macaca mulatta	DRD5	VGNC	VGNC:71991
Rattus norvegicus	DRD5	RGD	RGD:2523
Bos taurus	DRD5	VGNC	VGNC:109386
Mus musculus	DRD5	MGD	MGI:94927
Others	DRD5	NCBI