Il6st - interleukin 6 cytokine family signal transducer Gene

Also Known as Gp130; Ac1055; Il-6rb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25205

Summary

Predicted to enable several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and scaffold protein binding activity. Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Located in neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st Products (1)

mRNA Protein Name
NM_001008725.3 NP_001008725.2 interleukin-6 receptor subunit beta precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in interleukin-6-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18280048 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
17437036 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17322172 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15371280 RGD
involved in triglyceride mobilization IMP
IMP: Inferred from mutant phenotype
8843746 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8921254 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-6 receptor subunit beta

  • IL-6 receptor subunit beta

  • IL-6R subunit beta

  • interleukin 6 signal transducer

  • membrane glycoprotein 130

  • oncostatin-M receptor subunit alpha

Recombinant Il6st Proteins

Cat. No. Product Name Accession Purity
HY-P76374 gp130/IL6ST Protein, Rat (HEK293, His) NP_001008725.2 (Q23-E618) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76375 gp130/IL6ST Protein, Rat (HEK293, His-Fc) NP_001008725.2 (Q23-E618) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06778 IL6ST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17230 Il6st Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23683 Il6st Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6st NCBI NCBI:3572