Bdkrb2 - bradykinin receptor B2 Gene

Also Known as B2BKR; B2BRA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25245

About Bdkrb2

Primary_assembly 6: 124,472,566-124,502,497 forward strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 362 orthologues, 8 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 44.5), Uterus (RPKM 44.) and 8 other tissues.

Summary

Enables beta-2 Adrenergic Receptor binding activity and Bradykinin Receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Located in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (Bradykinin Receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb2 Products (2)

mRNA Protein Name
NM_173100.3 NP_775123.2 B2 bradykinin receptor isoform 2
NM_001270713.2 NP_001257642.1 B2 bradykinin receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
20150590 RGD
enables bradykinin receptor activity IDA
IDA: Inferred from direct assay
1715575 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12177051 RGD
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
7791078 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19565561 RGD
involved in maintenance of blood-brain barrier IDA
IDA: Inferred from direct assay
20080302 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
16507603 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12177051 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
15576455 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18190998 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bdkrb2 Protein Structure

7tmA_BK-2

7tmA_BK-2: cd15381 (65 - 349)

7tmA_BK-2

7tmA_BK-2: cd15381 (65 - 91)

7tmA_BK-2

7tmA_BK-2: cd15381 (98 - 123)

7tmA_BK-2

7tmA_BK-2: cd15381 (136 - 166)

7tmA_BK-2

7tmA_BK-2: cd15381 (179 - 200)

7tmA_BK-2

7tmA_BK-2: cd15381 (227 - 256)

7tmA_BK-2

7tmA_BK-2: cd15381 (269 - 299)

7tmA_BK-2

7tmA_BK-2: cd15381 (317 - 342)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

B2 bradykinin receptor

  • B2R

  • BK-2 receptor

  • bradykinin receptor, beta 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01457 BDKRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01458 Bdkrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01459 Bdkrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bdkrb2 NCBI NCBI:624