Acsl1 - acyl-CoA synthetase long-chain family member 1 Gene

Also Known as ACS; Acas; COAA; Facl2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25288

Summary

Enables arachidonate-CoA Ligase activity; oleoyl-CoA Ligase activity; and phytanate-CoA Ligase activity. Involved in several processes, including fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in bounding membrane of organelle; endoplasmic reticulum; and plasma membrane. Biomarker of obesity. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Acsl1 Products (1)

mRNA	Protein	Name
NM_012820.2	NP_036952.1	long-chain-fatty-acid--CoA ligase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate-CoA ligase activity	IDA IDA: Inferred from direct assay	28209804	RGD
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	10198260	RGD
enables oleoyl-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	23024797	RGD
enables phytanate-CoA ligase activity	IDA IDA: Inferred from direct assay	8978480	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	17028193	RGD
involved in fatty acid transport	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in long-chain fatty acid import into cell	IMP IMP: Inferred from mutant phenotype	23024797	RGD
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	10749848	RGD
involved in long-chain fatty-acyl-CoA biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in positive regulation of long-chain fatty acid import across plasma membrane	IDA IDA: Inferred from direct assay	24503477	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15811777	RGD
involved in response to oleic acid	IEP IEP: Inferred from expression pattern	16428347	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	10777552	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16428347	RGD
involved in triglyceride biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in very long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	8978480	RGD
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	10725307	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	17478130	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	24503477	RGD
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	23024797	RGD
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	14561759	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
long-chain-fatty-acid--CoA ligase 1	Acyl CoA synthetase, long chain LACS 1 arachidonate--CoA ligase fatty acid Coenzyme A ligase, long chain 2 long-chain acyl-CoA synthetase 1 long-chain-fatty-acid--CoA ligase, liver isozyme phytanate--CoA ligase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0723	Neomangiferin		99.80%	Unkown
HY-186096	LP-856866		99.92%	Unkown
HY-186095	LP-911888	Inhibitor	99.83%	Unkown
HY-RS00200	ACSL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS16255	Acsl1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS24003	Acsl1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acsl1	NCBI	NCBI:2180