Cst3 - cystatin C Gene

Also Known as CYSC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25307

Summary

Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (Cystatin C). [provided by Alliance of Genome Resources, Apr 2022]

Cst3 Products (1)

mRNA Protein Name
NM_012837.1 NP_036969.1 cystatin-C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase inhibitor activity IDA
IDA: Inferred from direct assay
8761177 RGD
enables protease binding IDA
IDA: Inferred from direct assay
2622871 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
9432134 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17440810 RGD
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
10930551 RGD
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16140167 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
16935259 RGD
involved in eye development IEP
IEP: Inferred from expression pattern
11431459 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
8286570 RGD
involved in positive regulation of DNA replication IDA
IDA: Inferred from direct assay
1540157 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
1540157 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
8738161 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
9222450 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16935259 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
8590041 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
18723004 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
2757396 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16414118 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16248890 RGD
involved in salivary gland development IEP
IEP: Inferred from expression pattern
10075146 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
14738488 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
15872057 RGD
located in cell projection IDA
IDA: Inferred from direct assay
16309830 RGD
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
8245434 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2689174 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
10950881 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14738488 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
15872057 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16414118 RGD
located in vesicle IDA
IDA: Inferred from direct assay
10950881 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystatin-C

  • Cystatin C (cysteine proteinase inhibitor)

  • cystatin-3

Recombinant Cst3 Proteins

Cat. No. Product Name Accession Purity
HY-P74209 Cystatin C/CST3 Protein, Rat (HEK293, His) P14841 (G21-A140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03264 CST3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18030 Cst3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24504 Cst3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cst3 NCBI NCBI:1471