Npy5r - neuropeptide Y receptor Y5 Gene

Also Known as NPYR5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25340

About Npy5r

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues.

Summary

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Located in cytoplasm. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r Products (3)

mRNA Protein Name
NM_012869.2 NP_037001.1 neuropeptide Y receptor type 5
XM_006253014.4 XP_006253076.1 neuropeptide Y receptor type 5 isoform X1
NM_012869.2 NP_037001.1 neuropeptide Y receptor type 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables neuropeptide Y receptor activity IDA
IDA: Inferred from direct assay
8824284 RGD
enables pancreatic polypeptide receptor activity IDA
IDA: Inferred from direct assay
8824284 RGD
enables peptide YY receptor activity IDA
IDA: Inferred from direct assay
8824284 RGD
Biological Process GO Annotation Evidence References Source
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
9795372 RGD
involved in generation of ovulation cycle rhythm IMP
IMP: Inferred from mutant phenotype
12047724 RGD
involved in negative regulation of acute inflammatory response to antigenic stimulus IDA
IDA: Inferred from direct assay
18805447 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12791184 RGD
involved in negative regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
12623227 RGD
involved in negative regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
11796508 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21595512 RGD
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
12161018 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21595512 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
12710532 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy5r Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 5

  • NPY-Y5 receptor

  • NPY5-R

  • NPYY5-R

  • Neuropeptide Y5 receptor

  • Y5 receptor

Related Diseases

Diseases Alias
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Dihydropyrimidinase Deficiency

  • Dihydropyrimidinuria

  • Dpys Deficiency

  • Dph Deficiency

  • DPYSD

  • Dihydrouracil Amidohydrolase Deficiency

  • Dihydropyrimidinuria Due To Dpys Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107734 L 152804 Antagonist 99.89% Unkown
HY-RS09520 NPY5R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npy5r NCBI NCBI:4889