ZBTB38 - zinc finger and BTB domain containing 38 Gene

Also Known as CIBZ; ZNF921; PPP1R171

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 253461

About ZBTB38

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,324,186-141,449,792 (from NCBI)

This gene has 23 transcripts (splice variants), 158 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 20.7), gall bladder (RPKM 13.0) and 24 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with Apoptosis in some cell types. [provided by RefSeq, Jun 2010]

ZBTB38 Products (85)

mRNA Protein Name
NM_001080412.3 NP_001073881.2 zinc finger and BTB domain-containing protein 38
NM_001350099.2 NP_001337028.1 zinc finger and BTB domain-containing protein 38
NM_001350100.2 NP_001337029.1 zinc finger and BTB domain-containing protein 38
NM_001376112.1 NP_001363041.1 zinc finger and BTB domain-containing protein 38
NM_001376113.1 NP_001363042.1 zinc finger and BTB domain-containing protein 38
NM_001376114.1 NP_001363043.1 zinc finger and BTB domain-containing protein 38
NM_001376115.1 NP_001363044.1 zinc finger and BTB domain-containing protein 38
NM_001376116.1 NP_001363045.1 zinc finger and BTB domain-containing protein 38
NM_001376117.1 NP_001363046.1 zinc finger and BTB domain-containing protein 38
NM_001376118.1 NP_001363047.1 zinc finger and BTB domain-containing protein 38
NM_001376119.1 NP_001363048.1 zinc finger and BTB domain-containing protein 38
NM_001376120.1 NP_001363049.1 zinc finger and BTB domain-containing protein 38
NM_001376121.1 NP_001363050.1 zinc finger and BTB domain-containing protein 38
NM_001376122.1 NP_001363051.1 zinc finger and BTB domain-containing protein 38
NM_001376123.1 NP_001363052.1 zinc finger and BTB domain-containing protein 38
NM_001376124.1 NP_001363053.1 zinc finger and BTB domain-containing protein 38
NM_001376125.1 NP_001363054.1 zinc finger and BTB domain-containing protein 38
NM_001376126.1 NP_001363055.1 zinc finger and BTB domain-containing protein 38
NM_001376127.1 NP_001363056.1 zinc finger and BTB domain-containing protein 38
NM_001376128.1 NP_001363057.1 zinc finger and BTB domain-containing protein 38
NM_001376142.1 NP_001363071.1 zinc finger and BTB domain-containing protein 38
NM_001376143.1 NP_001363072.1 zinc finger and BTB domain-containing protein 38
NM_001376150.1 NP_001363079.1 zinc finger and BTB domain-containing protein 38
NM_001376152.1 NP_001363081.1 zinc finger and BTB domain-containing protein 38
NM_001376157.1 NP_001363086.1 zinc finger and BTB domain-containing protein 38
NM_001376158.1 NP_001363087.1 zinc finger and BTB domain-containing protein 38
NM_001376159.1 NP_001363088.1 zinc finger and BTB domain-containing protein 38
NM_001376160.1 NP_001363089.1 zinc finger and BTB domain-containing protein 38
NM_001376161.1 NP_001363090.1 zinc finger and BTB domain-containing protein 38
NM_001376162.1 NP_001363091.1 zinc finger and BTB domain-containing protein 38
NM_001376163.1 NP_001363092.1 zinc finger and BTB domain-containing protein 38
NM_001376164.1 NP_001363093.1 zinc finger and BTB domain-containing protein 38
NM_001376165.1 NP_001363094.1 zinc finger and BTB domain-containing protein 38
NM_001376166.1 NP_001363095.1 zinc finger and BTB domain-containing protein 38
NM_001376167.1 NP_001363096.1 zinc finger and BTB domain-containing protein 38
NM_001376168.1 NP_001363097.1 zinc finger and BTB domain-containing protein 38
NM_001376169.1 NP_001363098.1 zinc finger and BTB domain-containing protein 38
NM_001376170.1 NP_001363099.1 zinc finger and BTB domain-containing protein 38
NM_001376171.1 NP_001363100.1 zinc finger and BTB domain-containing protein 38
NM_001376172.1 NP_001363101.1 zinc finger and BTB domain-containing protein 38
NM_001376173.1 NP_001363102.1 zinc finger and BTB domain-containing protein 38
NM_001376174.1 NP_001363103.1 zinc finger and BTB domain-containing protein 38
NM_001376175.1 NP_001363104.1 zinc finger and BTB domain-containing protein 38
NM_001376176.1 NP_001363105.1 zinc finger and BTB domain-containing protein 38
NM_001376177.1 NP_001363106.1 zinc finger and BTB domain-containing protein 38
NM_001376178.1 NP_001363107.1 zinc finger and BTB domain-containing protein 38
NM_001376179.1 NP_001363108.1 zinc finger and BTB domain-containing protein 38
NM_001376180.1 NP_001363109.1 zinc finger and BTB domain-containing protein 38
NM_001376181.1 NP_001363110.1 zinc finger and BTB domain-containing protein 38
NM_001376182.1 NP_001363111.1 zinc finger and BTB domain-containing protein 38
NM_001376183.1 NP_001363112.1 zinc finger and BTB domain-containing protein 38
NM_001376184.1 NP_001363113.1 zinc finger and BTB domain-containing protein 38
NM_001376185.1 NP_001363114.1 zinc finger and BTB domain-containing protein 38
NM_001376186.1 NP_001363115.1 zinc finger and BTB domain-containing protein 38
NM_001376187.1 NP_001363116.1 zinc finger and BTB domain-containing protein 38
NM_001376188.1 NP_001363117.1 zinc finger and BTB domain-containing protein 38
NM_001376189.1 NP_001363118.1 zinc finger and BTB domain-containing protein 38
NM_001376190.1 NP_001363119.1 zinc finger and BTB domain-containing protein 38
NM_001387941.1 NP_001374870.1 zinc finger and BTB domain-containing protein 38
NM_001387945.1 NP_001374874.1 zinc finger and BTB domain-containing protein 38
NM_001387947.1 NP_001374876.1 zinc finger and BTB domain-containing protein 38
NM_001387948.1 NP_001374877.1 zinc finger and BTB domain-containing protein 38
NM_001387950.1 NP_001374879.1 zinc finger and BTB domain-containing protein 38
NM_001387952.1 NP_001374881.1 zinc finger and BTB domain-containing protein 38
NM_001387953.1 NP_001374882.1 zinc finger and BTB domain-containing protein 38
NM_001387957.1 NP_001374886.1 zinc finger and BTB domain-containing protein 38
NM_001387959.1 NP_001374888.1 zinc finger and BTB domain-containing protein 38
NM_001387960.1 NP_001374889.1 zinc finger and BTB domain-containing protein 38
NM_001387962.1 NP_001374891.1 zinc finger and BTB domain-containing protein 38
NM_001387966.1 NP_001374895.1 zinc finger and BTB domain-containing protein 38
NM_001387967.1 NP_001374896.1 zinc finger and BTB domain-containing protein 38
NM_001387968.1 NP_001374897.1 zinc finger and BTB domain-containing protein 38
NM_001387969.1 NP_001374898.1 zinc finger and BTB domain-containing protein 38
NM_001387970.1 NP_001374899.1 zinc finger and BTB domain-containing protein 38
NM_001387971.1 NP_001374900.1 zinc finger and BTB domain-containing protein 38
NM_001387972.1 NP_001374901.1 zinc finger and BTB domain-containing protein 38
NM_001387973.1 NP_001374902.1 zinc finger and BTB domain-containing protein 38
NM_001387974.1 NP_001374903.1 zinc finger and BTB domain-containing protein 38
NM_001387975.1 NP_001374904.1 zinc finger and BTB domain-containing protein 38
NM_001387976.1 NP_001374905.1 zinc finger and BTB domain-containing protein 38
NM_001387977.1 NP_001374906.1 zinc finger and BTB domain-containing protein 38
NM_001387978.1 NP_001374907.1 zinc finger and BTB domain-containing protein 38
NM_001387979.1 NP_001374908.1 zinc finger and BTB domain-containing protein 38
NM_001387980.1 NP_001374909.1 zinc finger and BTB domain-containing protein 38
NM_001387981.1 NP_001374910.1 zinc finger and BTB domain-containing protein 38

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
16354688 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16354688 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16354688 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
24726359 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16354688 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
24726359 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16354688 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB38 Protein Structure

BTB

BTB: BTB/POZ domain (24 - 128)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (343 - 365)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (373 - 391)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (461 - 483)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (505 - 526)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1026 - 1049)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1053 - 1077)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (1082 - 1105)

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  • 1196 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 38

  • protein phosphatase 1, regulatory subunit 171

ZBTB38 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB38 Q8NAP3 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
ZBTB38 Q8NAP3 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
ZBTB38 Q8NAP3 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
ZBTB38 Q8NAP3 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
28514442
Intra
ZBTB38 Q8NAP3 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
33961781
Intra
ZBTB38 Q8NAP3 TPP1 Homo sapiens O14773
Validated Y2H
32814053
Intra
ZBTB38 Q8NAP3 TPP1 Homo sapiens O14773
Y2H Pooling
32814053
Intra
ZBTB38 Q8NAP3 TPP1 Homo sapiens O14773
Y2H Array
32814053
Intra
ZBTB38 Q8NAP3 CARF Homo sapiens Q8N187
Y2H Pooling
32814053
Intra
ZBTB38 Q8NAP3 CARF Homo sapiens Q8N187
Validated Y2H
32814053
Intra
ZBTB38 Q8NAP3 CARF Homo sapiens Q8N187
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pigmented Paravenous Chorioretinal Atrophy

  • Pigmented Paravenous Retinochoroidal Atrophy

  • PPCRA

  • Pprca

  • Atrophy, Chorioretinal, Pigmented Paravenous
Kuru

  • Kuru, Susceptibility To

  • Kuru Encephalopathy

  • Kuru Encephalitis

  • Kuru Disease
Acromesomelic Dysplasia 2b

  • Fibular Hypoplasia And Complex Brachydactyly

  • Du Pan Syndrome

  • AMD2B

  • Dupans

  • Acromesomelic Dysplasia-2b

  • Fibular Aplasia-Complex Brachydactyly Syndrome
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15973 ZBTB38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZBTB38 MGD MGI:2442866
Bos taurus ZBTB38 VGNC VGNC:37076
Canis familiaris ZBTB38 VGNC VGNC:48534
Macaca mulatta ZBTB38 VGNC VGNC:79629
Felis catus ZBTB38 VGNC VGNC:67168
Rattus norvegicus ZBTB38 RGD RGD:1310136
Others ZBTB38 NCBI