Adk - adenosine kinase Gene

Also Known as AK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25368

About Adk

Primary_assembly 15: 2,863,244-3,246,510 reverse strand.mRatBN7.2:CM026988.1

This gene has 2 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 17 phenotypes. Biased expression in Liver (RPKM 121.9), Kidney (RPKM 595.5) and 9 other tissues.

Summary

Enables Adenosine Kinase activity. Involved in several processes, including adenosine metabolic process; circadian regulation of gene expression; and type B pancreatic cell proliferation. Located in cytoplasm and nucleus. Used to study brain infarction. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in hypermethioninemia due to Adenosine Kinase deficiency. Orthologous to human ADK (Adenosine Kinase). [provided by Alliance of Genome Resources, Apr 2022]

Adk Products (1)

mRNA Protein Name
NM_012895.3 NP_037027.2 adenosine kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenosine kinase activity IDA
IDA: Inferred from direct assay
11833783 RGD
Biological Process GO Annotation Evidence References Source
involved in adenosine metabolic process IDA
IDA: Inferred from direct assay
12675911 RGD
involved in circadian regulation of gene expression IEP
IEP: Inferred from expression pattern
12675911 RGD
involved in positive regulation of T cell proliferation IEP
IEP: Inferred from expression pattern
16827901 RGD
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16827901 RGD
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
21335462 RGD
involved in type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
22345561 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adk Protein Structure

ribokinase_pfkB_like

ribokinase_pfkB_like: cl00192 (69 - 401)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

adenosine kinase

  • adenosine 5'-phosphotransferase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P2952 Recombinant myokinase, Rabbit muscle / Phase 4

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00505 AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145654 MRS-4203 Inhibitor / Unkown
HY-RS00383 ADK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00384 Adk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00385 Adk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adk NCBI NCBI:132