ADK - adenosine kinase Gene

Also Known as AK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132

About ADK

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:74,151,221-74,709,290 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues.

Summary

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ADK Products (15)

mRNA Protein Name
NM_001369123.1 NP_001356052.1 adenosine kinase isoform e
XM_017015703.3 XP_016871192.1 adenosine kinase isoform X5
XM_017015706.2 XP_016871195.1 adenosine kinase isoform X8
NM_001123.4 NP_001114.2 adenosine kinase isoform a
XM_017015699.2 XP_016871188.1 adenosine kinase isoform X3
NM_001202449.2 NP_001189378.1 adenosine kinase isoform c
NM_001202450.2 NP_001189379.1 adenosine kinase isoform d
XM_017015698.2 XP_016871187.1 adenosine kinase isoform X1
NM_006721.4 NP_006712.2 adenosine kinase isoform b
XM_047424621.1 XP_047280577.1 adenosine kinase isoform X9
XM_017015705.2 XP_016871194.1 adenosine kinase isoform X7
XM_017015704.2 XP_016871193.1 adenosine kinase isoform X6
XM_017015702.2 XP_016871191.1 adenosine kinase isoform X4
XM_047424620.1 XP_047280576.1 adenosine kinase isoform X2
NM_001369124.1 NP_001356053.1 adenosine kinase isoform f

ADK Protein Structure

PfkB

PfkB: pfkB family carbohydrate kinase (44 - 356)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

adenosine kinase

  • adenosine 5'-phosphotransferase

  • testicular tissue protein Li 14

Recombinant ADK Proteins

Cat. No. Product Name Accession Purity
HY-P75529 ADK/Adenosine Kinase Protein, Human (sf9, His-GST) AAH03568 (M1-H345) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75530 ADK/Adenosine Kinase Protein, Human (HEK293) AAH03568.1 (M1-H345) ≥ 95%, as determined by reducing SDS-PAGE.

ADK Antibodies

Cat. No. Product Name Application Reactivity
HY-P82944 ADK Antibody (YA2689) WB, IHC-P Human, Mouse, Rat
HY-P82944A ADK Antibody (YA2689)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Splenic Tuberculosis

  • Tuberculosis, Splenic
Hypermethioninemia

  • Hepatic Methionine Adenosyltransferase Deficiency

  • Glycine N-Methyltransferase Deficiency

  • Met

  • S-Adenosylhomocysteine Hydrolase Deficiency

  • Deficiency Of Methionine Adenosyltransferase

  • Gnmt Deficiency

  • Mat Deficiency

  • Methionine Adenosyltransferase Deficiency

  • Methioninemia

  • Deficiency Of Acetyl-Coa Acetyltransferase
Purine-Pyrimidine Metabolic Disorder

  • Inborn Errors Of Purine-Pyrimidine Metabolism

  • Disorder Of Purine Or Pyrimidine Metabolism
Hypermethioninemia Due To Adenosine Kinase Deficiency

  • Adk Hypermethioninemia

  • Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

  • Hypermethioninemia Encephalopathy Due To Adk Deficiency

  • Mrt8

  • Mental Retardation, Autosomal Recessive 8, Formerly

  • Mrt8, Formerly

  • HMAKD

  • Mental Retardation, Autosomal Recessive 8
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P2952 Recombinant myokinase, Rabbit muscle / Phase 4

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00505 AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145654 MRS-4203 Inhibitor / Unkown
HY-RS00383 ADK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00384 Adk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00385 Adk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADK RGD RGD:2046
Canis familiaris ADK VGNC VGNC:37659
Mus musculus ADK MGD MGI:87930
Macaca mulatta ADK VGNC VGNC:69698
Felis catus ADK VGNC VGNC:59644
Others ADK NCBI