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  2. ADK - adenosine kinase Gene

ADK - adenosine kinase Gene

Homo sapiens

Also known as AK

Gene ID: 132 | Gene type: protein coding

About ADK

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:74,151,221-74,709,290 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues.

Summary

This gene an Enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the Enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ADK Products(15)

mRNA Protein Name
NM_001369123.1 NP_001356052.1 adenosine kinase isoform e
XM_017015703.3 XP_016871192.1 adenosine kinase isoform X5
XM_017015706.2 XP_016871195.1 adenosine kinase isoform X8
NM_001123.4 NP_001114.2 adenosine kinase isoform a
XM_017015699.2 XP_016871188.1 adenosine kinase isoform X3
NM_001202449.2 NP_001189378.1 adenosine kinase isoform c
NM_001202450.2 NP_001189379.1 adenosine kinase isoform d
XM_017015698.2 XP_016871187.1 adenosine kinase isoform X1
NM_006721.4 NP_006712.2 adenosine kinase isoform b
XM_047424621.1 XP_047280577.1 adenosine kinase isoform X9
XM_017015705.2 XP_016871194.1 adenosine kinase isoform X7
XM_017015704.2 XP_016871193.1 adenosine kinase isoform X6
XM_017015702.2 XP_016871191.1 adenosine kinase isoform X4
XM_047424620.1 XP_047280576.1 adenosine kinase isoform X2
NM_001369124.1 NP_001356053.1 adenosine kinase isoform f

ADK Protein Structure

PfkB

PfkB: pfkB family carbohydrate kinase (44 - 356)

  • 0
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  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

adenosine kinase

adenosine 5'-phosphotransferase

testicular tissue protein Li 14

Recombinant ADK Proteins

Cat. No. Product Name Accession Purity
HY-P75529 ADK/Adenosine Kinase Protein, Human (sf9, His-GST) AAH03568 (M1-H345) ≥95%
HY-P75530 ADK/Adenosine Kinase Protein, Human (HEK293) AAH03568 (M1-H345) ≥95%

Related Diseases

Diseases Alias
Splenic Tuberculosis

Tuberculosis, Splenic

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Deficiency Of Methionine Adenosyltransferase

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia

Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

Hypermethioninemia Encephalopathy Due To Adk Deficiency

Mrt8

Mental Retardation, Autosomal Recessive 8, Formerly

Mrt8, Formerly

HMAKD

Mental Retardation, Autosomal Recessive 8

Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADK RGD RGD:2046
Canis familiaris ADK VGNC VGNC:37659
Mus musculus ADK MGD MGI:87930
Macaca mulatta ADK VGNC VGNC:69698
Felis catus ADK VGNC VGNC:59644
Others ADK NCBI