Aldh3a1 - aldehyde dehydrogenase 3 family, member A1 Gene

Also Known as AHDC; Aldh; Ahd-c; Aldh3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25375

About Aldh3a1

Primary_assembly 10: 45,892,924-45,902,681 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 370 orthologues, 20 paralogues and is associated with 5 phenotypes. Biased expression in Lung (RPKM 46.8), Heart (RPKM 25.7) and 4 other tissues.

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh3a1 Products (1)

mRNA Protein Name
NM_031972.2 NP_114178.1 aldehyde dehydrogenase, dimeric NADP-preferring

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: Inferred from direct assay
2831537 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12604187 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
9013560 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
10101022 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
11306047 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
7751973 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
18203689 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12604189 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10323327 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10323328 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11306046 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh3a1 Protein Structure

ALDH_F3AB

ALDH_F3AB: cd07132 (4 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, dimeric NADP-preferring

  • Aldehyde dehydrogenase (Ahd-c)

  • HTC-ALDH

  • aldehyde dehydrogenase 3A1

  • aldehyde dehydrogenase class 3

  • aldehyde dehydrogenase family 3 member A1

  • aldehyde dehydrogenase family 3 subfamily A1

  • tumor-associated aldehyde dehydrogenase tumor ALDH

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride 99.12% Unkown

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123962 G6PD activator AG1 99.54% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-144670 ALDH3A1-IN-1 Inhibitor 99.85% Unkown
HY-W017186 ALDH1A3-IN-3 Inhibitor 99.26% Unkown
HY-122577 EN40 Inhibitor 99.33% Unkown
HY-144669 ALDH1A3-IN-2 Inhibitor 99.85% Unkown
HY-146683 KS106 99.87% Unkown
HY-146682 KS100 99.61% Unkown
HY-RS00571 ALDH3A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-134917 Aldi-2 Inhibitor / Unkown
HY-144671 ALDH3A1-IN-2 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-184776 Dyclonine / Unkown
HY-B0364AS Dyclonine-d9 hydrochloride / Unkown
HY-D3442 ALDH2 probe 5 Ligand / Unkown
HY-RS00572 Aldh3a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00573 Aldh3a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21982 Aldh3b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28499 Aldh3b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh3a1 NCBI NCBI:218