Hbegf - heparin-binding EGF-like growth factor Gene

Also Known as Dtr; GFHB; Hegfl; Hb-egf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25433

Summary

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hbegf Products (1)

mRNA Protein Name
NM_012945.2 NP_037077.1 proheparin-binding EGF-like growth factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IMP
IMP: Inferred from mutant phenotype
15486316 RGD
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
15486316 RGD
Biological Process GO Annotation Evidence References Source
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15486316 RGD
involved in negative regulation of elastin biosynthetic process IDA
IDA: Inferred from direct assay
12882762 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
11956950 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proheparin-binding EGF-like growth factor

  • Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)

  • heparin binding epidermal growth factor-like growth factor

  • heparin-binding epidermal -growth - like growth factor

  • heparin-binding epidermal -growth factor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990609 KHK-2866 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180536 HB-EGF-IN-1 Inhibitor / Unkown
HY-D2004 ATTO 488 streptavidin / Unkown
HY-RS06029 HBEGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174671 Human HBEGF mRNA / Unkown
HY-RS17058 Hbegf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23502 Hbegf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hbegf NCBI NCBI:1839