HB-EGF-IN-1
HB-EGF-IN-1 is a HB-EGF inhibitor. HB-EGF-IN-1 binds to HB-EGF and blocks its interaction with EGFR and HER4, thereby inhibiting HB-EGF-mediated signaling. HB-EGF-IN-1 inhibits the PI3K-AKT signaling pathway, inducing cell cycle arrest and apoptosis. HB-EGF-IN-1 can be used for research on lung squamous cell carcinoma.
For research use only. We do not sell to patients.
- Formula: C49H64N6O11
- Molecular Weight:913.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:As-T cells
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Concentration:10 µg/mL
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Incubation Time:0, 24, 48, 72, and 96 h
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Result:Inhibited As-T cell proliferation at 0, 24, 48, 72, and 96 h.
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Cell Line:NCI-H226 cells
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Concentration:10 µg/mL
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Incubation Time:0, 24, 48, 72, and 96 h
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Result:Inhibited NCI-H226 cell proliferation at 0, 24, 48, 72, and 96 h.
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Cell Line:PC-9 cells
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Concentration:10 µg/mL
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Incubation Time:0, 24, 48, 72, and 96 h
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Result:Inhibited PC-9 cell proliferation at 0, 24, 48, 72, and 96 h.
In Vivo
HB-EGF-IN-1 (5 mg/kg; intramuscular injection; daily; Day 14-Day 25) reduces NCI-H226 xenograft tumor growth[1].
HB-EGF-IN-1 (5 mg/kg; intramuscular injection; daily; Day 14-Day 25) reduces PC-9 xenograft tumor growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (male, 4 weeks old) injected with As-T cells[1]
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Dosage:5 mg/kg (100 µL)
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Administration:intramuscular injection; daily; Day 14-Day 25
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Result:Reduced As-T xenograft tumor weight and tumor volume relative to control.
Tumor volume remained lower across the measured Day 1-Day 10 period.
The inhibitory effect on As-T tumor growth was greater than that of Afatinib.
HE staining showed inhibited malignant progression.
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Animal Model:BALB/c nude (male, 4 weeks old) injected with NCI-H22 cells[1]
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Dosage:5 mg/kg (100 µL)
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Administration:intramuscular injection; daily; Day 14-Day 25
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Result:Reduced NCI-H226 xenograft tumor weight and tumor volume relative to control.
Tumor volume remained lower across the measured Day 1-Day 10 period.
The inhibitory effect on NCI-H226 tumor growth was less than that of Afatinib.
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Animal Model:BALB/c nude (male, 4 weeks old) injected with PC-9 cells[1]
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Dosage:5 mg/kg (100 µL)
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Administration:intramuscular injection; daily; Day 14-Day 25
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Result:Reduced PC-9 xenograft tumor weight and tumor volume relative to control.
Tumor volume remained lower across the measured Day 1-Day 10 period.
The inhibitory effect on PC-9 tumor growth was less than that of Afatinib.
HE staining showed inhibited malignant progression.
Chemical Information
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Molecular Weight 913.07
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Formula C49H64N6O11
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC(C)([C@H](C(NC(CC([O-])=O)(/C(N)=N/C(N)=[N+](C)/C)N)=O)OC(C1=CC=CC=C1OC(C2=CC=CC=C2OC(C)=O)=O)=O)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HB-EGF-IN-1 Related Classifications
HY-180536 Related Classifications
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