Lhcgr - luteinizing hormone/choriogonadotropin receptor Gene

Also Known as Lhr; LSHR; LSH-R; LH/CG-R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25477

Summary

Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of Adenylate Cyclase activity; and arachidonic acid secretion. Located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Is integral component of plasma membrane and intrinsic component of external side of plasma membrane. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lhcgr Products (1)

mRNA Protein Name
NM_012978.2 NP_037110.1 lutropin-choriogonadotropic hormone receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
17588601 RGD
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
2502842 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11266505 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
2601325 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
15901736 RGD
enables peptide hormone binding IMP
IMP: Inferred from mutant phenotype
1714448 RGD
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
2601325 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
8440169 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
2502842 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
1714448 RGD
involved in arachidonate secretion IDA
IDA: Inferred from direct assay
9291830 RGD
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
2502842 RGD
involved in luteinizing hormone signaling pathway IDA
IDA: Inferred from direct assay
3030841 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
3026357 RGD
involved in positive regulation of calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
8187959 RGD
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
8187959 RGD
involved in positive regulation of hormone biosynthetic process IDA
IDA: Inferred from direct assay
3026357 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
8187959 RGD
involved in protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
10847593 RGD
involved in regulation of steroid biosynthetic process IEP
IEP: Inferred from expression pattern
17241129 RGD
involved in response to luteinizing hormone IDA
IDA: Inferred from direct assay
9553128 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9653071 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
10847593 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2174034 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
11266505 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lutropin-choriogonadotropic hormone receptor

  • LH receptor

  • LH/CG receptor

  • luteinizing hormone receptor

  • luteinizing hormone/chorionic gonadotropin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150210 FSHR agonist 1 Agonist 99.45% Unkown
HY-100271 Org41841 Agonist 99.77% Unkown
HY-RS07624 LHCGR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10594 Myr-Arf1(2–17) / Unkown
HY-RS17915 Lhcgr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24384 Lhcgr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lhcgr NCBI NCBI:3973