Agrn - agrin Gene

Also Known as AGR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25592

Summary

Enables calcium ion binding activity; cytokine binding activity; and dystroglycan binding activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of nitrogen compound metabolic process; and synapse organization. Acts upstream of or within receptor clustering. Located in axonal growth cone; basement membrane; and synapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Apr 2022]

Agrn Products (1)

mRNA Protein Name
NM_175754.2 NP_786930.2 agrin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BMP binding IPI
IPI: Inferred from physical interaction
20505824 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
20566625 RGD
enables dystroglycan binding IDA
IDA: Inferred from direct assay
8693000 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8205617 RGD
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
20505824 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
15883200 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
20471381 RGD
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
20471381 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
18957220 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22302937 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12796478 RGD
acts upstream of or within receptor clustering IDA
IDA: Inferred from direct assay
15155732 RGD
involved in regulation of axon guidance IDA
IDA: Inferred from direct assay
17870250 RGD
involved in regulation of microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
17870250 RGD
involved in regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18848351 RGD
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
19524020 RGD
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
19524020 RGD
involved in skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18957220 RGD
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
22302937 RGD
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
12486121 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
14697677 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
15711988 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19524020 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19524020 RGD
located in synapse IDA
IDA: Inferred from direct assay
12796478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

agrin

Agrn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Agrn P25304 Lrp4 Mus musculus Q8VI56
Pull Down
18848351
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00464 AGRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19873 Agrn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26372 Agrn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agrn NCBI NCBI:375790