Gnai3 - G protein subunit alpha i3 Gene

Also Known as GIP3A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25643

Summary

Enables G protein-coupled serotonin receptor binding activity; GTPase activating protein binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in membrane raft; plasma membrane; and zymogen granule. Biomarker of hypertension. Orthologous to human GNAI3 (G protein subunit alpha i3). [provided by Alliance of Genome Resources, Apr 2022]

Gnai3 Products (1)

mRNA Protein Name
NM_013106.2 NP_037238.1 guanine nucleotide-binding protein G(i) subunit alpha-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor binding IPI
IPI: Inferred from physical interaction
16772521 RGD
enables GTPase activating protein binding IPI
IPI: Inferred from physical interaction
11387333 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8524874 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11387333 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
25633408 RGD
involved in positive regulation of NAD(P)H oxidase activity IMP
IMP: Inferred from mutant phenotype
27912212 RGD
involved in positive regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
27912212 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
27912212 RGD
involved in vesicle fusion IDA
IDA: Inferred from direct assay
12038977 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11387333 RGD
located in zymogen granule IDA
IDA: Inferred from direct assay
12038977 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-3

  • Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3

  • g(i) alpha-3

  • guanine nucleotide binding protein (G protein), alpha inhibiting 3

  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

  • guanine nucleot

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05536 GNAI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20413 Gnai3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26922 Gnai3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnai3 NCBI NCBI:2773