Ppard - peroxisome proliferator-activated receptor delta Gene

Also Known as Pparb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25682

About Ppard

Primary_assembly 20: 6,298,785-6,363,968 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 19 phenotypes. Biased expression in Heart (RPKM 3.7), Adrenal (RPKM 23.1) and 9 other tissues.

Summary

Enables NF-kappaB binding activity and fatty acid binding activity. Involved in several processes, including decidualization; negative regulation of Collagen biosynthetic process; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard Products (1)

mRNA Protein Name
NM_013141.2 NP_037273.2 peroxisome proliferator-activated receptor delta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
15728586 RGD
enables fatty acid binding IDA
IDA: Inferred from direct assay
12600885 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
15728586 RGD
involved in decidualization IEP
IEP: Inferred from expression pattern
12773104 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
12773104 RGD
involved in fatty acid oxidation IDA
IDA: Inferred from direct assay
12600885 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15754086 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16337160 RGD
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
18293166 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
17346664 RGD
involved in negative regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
18585719 RGD
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
18585719 RGD
involved in phospholipid biosynthetic process IDA
IDA: Inferred from direct assay
17148578 RGD
involved in positive regulation of epidermis development IDA
IDA: Inferred from direct assay
19675577 RGD
involved in positive regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
19965574 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
19965574 RGD
involved in proteoglycan metabolic process IDA
IDA: Inferred from direct assay
17140817 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20233940 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18573863 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
19342198 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
19906781 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppard Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (71 - 154)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (171 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor delta

  • peroxisome proliferator activator receptor beta

  • peroxisome proliferator activator receptor, delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10922 PPARD Human Pre-designed siRNA Set A / Unkown
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A / Unkown
HY-121579 L-764406 Agonist / Unkown
HY-RS10924 Ppard Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppard NCBI NCBI:5467