Htr5a - 5-hydroxytryptamine receptor 5A Gene

Also Known as MR22; 5HT5A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25689

About Htr5a

Primary_assembly 4: 7,444,968-7,454,651 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 2 phenotypes. Restricted expression toward (RPKM 3.).

Summary

Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; hippocampus development; and response to estradiol. Located in several cellular components, including Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Is integral component of postsynaptic specialization membrane. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Apr 2022]

Htr5a Products (1)

mRNA Protein Name
NM_013148.2 NP_037280.1 5-hydroxytryptamine receptor 5A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IMP
IMP: Inferred from mutant phenotype
7682702 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
IMP: Inferred from mutant phenotype
10861802 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
16572590 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17122082 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
17394137 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15282708 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
16082681 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr5a Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (40 - 348)

7tm_GPCRs

7tm_GPCRs: cd14964 (42 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (75 - 97)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (159 - 175)

7tm_GPCRs

7tm_GPCRs: cd14964 (197 - 220)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 305)

7tm_GPCRs

7tm_GPCRs: cd14964 (316 - 341)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 5A

  • 5-HT-5A

  • 5-HT5A

  • 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

  • REC17

  • serotonin receptor 5A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06477 HTR5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06478 Htr5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06479 Htr5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr5a NCBI NCBI:3361