Hmbs - hydroxymethylbilane synthase Gene

Also Known as PBGD; hemC; PBG-D; URO-S

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25709

Summary

Enables several functions, including amine binding activity; hydroxymethylbilane synthase activity; and uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to lead ion; and response to estradiol. Located in several cellular components, including axon; cytosol; and perinuclear region of cytoplasm. Colocalizes with condensed chromosome. Biomarker of bilirubin metabolic disorder and liver carcinoma. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]

Hmbs Products (1)

mRNA Protein Name
NM_013168.2 NP_037300.2 porphobilinogen deaminase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amine binding IPI
IPI: Inferred from physical interaction
9344466 RGD
enables carboxylic acid binding IPI
IPI: Inferred from physical interaction
9344466 RGD
enables hydroxymethylbilane synthase activity IDA
IDA: Inferred from direct assay
593266 RGD
enables hydroxymethylbilane synthase activity IMP
IMP: Inferred from mutant phenotype
18760440 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12917623 RGD
enables uroporphyrinogen-III synthase activity IDA
IDA: Inferred from direct assay
6466301 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
2886336 RGD
involved in astrocyte differentiation IEP
IEP: Inferred from expression pattern
12917623 RGD
involved in cellular response to amine stimulus IEP
IEP: Inferred from expression pattern
10416273 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
19688726 RGD
involved in cellular response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
10416273 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
4019471 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
7917467 RGD
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
16566714 RGD
involved in liver development IDA
IDA: Inferred from direct assay
971328 RGD
involved in porphyrin-containing compound biosynthetic process IDA
IDA: Inferred from direct assay
971328 RGD
involved in porphyrin-containing compound metabolic process IDA
IDA: Inferred from direct assay
593266 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
8295845 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
17285311 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
6688350 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10416826 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
9468112 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
3697363 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
16566714 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
4040350 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
3327437 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
8000239 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
3580703 RGD
involved in response to vitamin IEP
IEP: Inferred from expression pattern
9559098 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
6893114 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10571258 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
8582750 RGD
involved in tetrapyrrole biosynthetic process IDA
IDA: Inferred from direct assay
6712591 RGD
involved in tetrapyrrole biosynthetic process IMP
IMP: Inferred from mutant phenotype
18760440 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11202056 RGD
located in condensed chromosome IDA
IDA: Inferred from direct assay
12917623 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11202056 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

porphobilinogen deaminase

  • alternative name: porphobilinogen deaminase

  • pre-uroporphyrinogen synthase

  • uroporphyrinogen I synthase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991029 Sutacimig Activator 99.08% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119524 Clofibride / Unkown
HY-137281 HMB-Val-Ser-Leu-VE Inhibitor / Unkown
HY-RS06224 HMBS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18945 Hmbs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25435 Hmbs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmbs NCBI NCBI:3145