GUCY2C - Gucy2c guanylate cyclase 2C Gene

Also Known as GCC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25711

Summary

Enables Guanylate Cyclase activity and toxic substance binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (Guanylate Cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]

GUCY2C Products (1)

mRNA Protein Name
NM_013170.1 NP_037302.1 guanylyl cyclase C precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables guanylate cyclase activity IDA
IDA: Inferred from direct assay
1701694 RGD
enables toxic substance binding IDA
IDA: Inferred from direct assay
1701694 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylyl cyclase C

heat-stable enterotoxin receptor

  • GC-C

  • Guanylate cyclase 2C (heat stable enterotoxin receptor)

  • STA receptor

  • intestinal guanylate cyclase

Recombinant GUCY2C Proteins

Cat. No. Product Name Accession Purity
HY-P71666 GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) P23897 (S23-Q429) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175615A RSL3-NH2 hydrochloride / Unkown
HY-175615 RSL3-NH2 / Unkown
HY-RS05921 GUCY2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16946 Gucy2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23389 Gucy2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99232 Indusatumab ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GUCY2C NCBI NCBI:2984