NEGR1 - neuronal growth regulator 1 Gene

Also Known as Ntra; KILON; IGLON4; DMML2433

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 257194

About NEGR1

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:71,395,943-72,282,539 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 5 paralogues. Broad expression in brain (RPKM 13.7), fat (RPKM 5.3) and 18 other tissues.

Summary

Predicted to act upstream of or within several processes, including feeding behavior; locomotory behavior; and positive regulation of neuron projection development. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NEGR1 Products (1)

mRNA Protein Name
NM_173808.3 NP_776169.2 neuronal growth regulator 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEGR1 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (46 - 135)

I-set

I-set: Immunoglobulin I-set domain (139 - 209)

I-set

I-set: Immunoglobulin I-set domain (228 - 312)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

neuronal growth regulator 1

  • IgLON family member 4

NEGR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEGR1 Q7Z3B1 NPC2 Homo sapiens P61916
Pull Down
27940359
Intra
NEGR1 Q7Z3B1 NPC2 Homo sapiens P61916
Anti Bait CoIP
27940359
Intra
NEGR1 Q7Z3B1 NPC2 Homo sapiens P61916
Y2H
27940359
Intra
NEGR1 Q7Z3B1 NPC2 Homo sapiens P61916
IF
27940359
Intra
NEGR1 Q7Z3B1 SYNGAP1 Homo sapiens Q96PV0
Anti Bait CoIP
37207277
Intra
NEGR1 Q7Z3B1 LSAMP Homo sapiens Q13449
Protein Array
21982860
Intra
NEGR1 Q7Z3B1 NTM Homo sapiens Q9P121
Protein Array
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEGR1 Proteins

Cat. No. Product Name Accession Purity
HY-P76508 NEGR1 Protein, Human (HEK293, His) Q7Z3B1-1 (V38-G324) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

  • NPC2

  • Niemann-Pick Disease Type C2

  • Niemann-Pick C2 Disease

  • Niemann-Pick Disease C2
Niemann-Pick Disease

  • Sphingomyelin/Cholesterol Lipidosis

  • Niemann-Pick Diseases

  • Lipoid Histiocytosis

  • Sphingomyelin Lipidosis

  • Sphingomyelinase Deficiency Disease

  • Lipid Histiocytosis

  • Neuronal Cholesterol Lipidosis

  • Neuronal Lipidosis

  • Npd

  • Sphingomyelinase Deficiency

  • Niemann-Pick Disease, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09186 NEGR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18671 Negr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25157 Negr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NEGR1 RGD RGD:708416
Bos taurus NEGR1 VGNC VGNC:106836
Mus musculus NEGR1 MGD MGI:2444846
Macaca mulatta NEGR1 VGNC VGNC:81481
Felis catus NEGR1 VGNC VGNC:107589
Canis familiaris NEGR1 VGNC VGNC:54049
Others NEGR1 NCBI