Itgb4 - integrin subunit beta 4 Gene

Predicted to enable G protein-coupled receptor binding activity and Integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex and membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa non-Herlitz type and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (Integrin subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]