GALK2 - galactokinase 2 Gene

Homo sapiens

Also known as GK2

Gene ID: 2585 | Gene type: protein coding

About GALK2

Cytogenetic location: 15q21.1-q21.2 Genomic coordinates (GRCh38): 15:49,155,774-49,367,740 (from NCBI)

This gene has 22 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 4.3), duodenum (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

GALK2 Products(6)

mRNA	Protein	Name
NM_001001556.3	NP_001001556.1	N-acetylgalactosamine kinase isoform 2
NM_001289030.2	NP_001275959.1	N-acetylgalactosamine kinase isoform 3
NM_001289031.1	NP_001275960.1	N-acetylgalactosamine kinase isoform 3
NM_001352047.1	NP_001338976.1	N-acetylgalactosamine kinase isoform 4
NM_001352048.2	NP_001338977.1	N-acetylgalactosamine kinase isoform 4
NM_002044.4	NP_002035.1	N-acetylgalactosamine kinase isoform 1

GALK2 Protein Structure

GalKase_gal_bdg

GHMP_kinases_N

GHMP_kinases_C

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

N-acetylgalactosamine kinase

galNAc kinase

Recombinant GALK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70404	N-acetylgalactosamine kinase/GALK2 Protein, Human (HEK293, His)	Q01415 (M1-A458)	≥95%

Related Diseases

Diseases

Alias

Galactosemia I

Galactosemia	Galt Deficiency
Classic Galactosemia	Galactose-1-Phosphate Uridylyltransferase Deficiency
Galactose-1-Phosphate Uridyltransferase Deficiency	GALAC1
Galactosemia, Classic	Galactosemia Type 1
Galactosemias	Classical Galactosemia
Galactosaemia	Galactose Intolerance
Epimerase Deficiency Galactosemia	Galactokinase Deficiency Disease
Galactose Epimerase Deficiency	Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease
Gale Deficiency	Galk Deficiency
Udp-Galactose-4-Epimerase Deficiency Disease	Utp Hexose-1-Phosphate Uridylyltransferase Deficiency
Galactosemia 1	Galactosemia, Duarte Variant
Deficiency Of Galactokinase	Udpglucose 4-Epimerase Deficiency Disease
Classical Galactosaemia	Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency
Classic Galactosaemia	Deficiency Of Hexose-1-Phosphate Uridylyltransferase
Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase	Deficiency Of Galactose-1-Phosphate Uridylyltransferase
Galactose-1-Phosphate Uridyl Transferase Deficiency	Transferase Deficiency Galactosemia
Deficiency Of Uridyl Transferase	Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase
Utp-Hexose-1-Phosphate Uridyltransferase Deficiency

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Galactosemia Ii

Galactokinase Deficiency	Galk Deficiency
Galactokinase Deficiency With Cataracts	Deficiency Of Galactokinase
GALAC2	Galk-D
Galactokinase Deficiency Galactosemia	Galactosemia 2
Galactosemia Type 2	Hereditary Galactokinase Deficiency
Galactokinase Deficiency, Cataract	Galactosemias
Galk - [Galactokinase Deficiency]

Superficial Keratitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05244	GALK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GALK2	VGNC	VGNC:41082
Macaca mulatta	GALK2	VGNC	VGNC:72870
Felis catus	GALK2	VGNC	VGNC:62440
Mus musculus	GALK2	MGD	MGI:1917226
Bos taurus	GALK2	VGNC	VGNC:29220
Rattus norvegicus	GALK2	RGD	RGD:1308691
Others	GALK2	NCBI

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