Klk8 - kallikrein related-peptidase 8 Gene

Also Known as NP; BSP1; Nrpn; Prss19

Species: Mus musculus

Gene Type: protein coding
Gene ID: 259277

Summary

This gene encodes a member of the Kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related Kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]

Klk8 Products (2)

mRNA Protein Name
NM_001324398.1 NP_001311327.1 kallikrein-8 preproprotein
NM_008940.3 NP_032966.1 kallikrein-8 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
28267150 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
28267150 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
9556608 MGI
Biological Process GO Annotation Evidence References Source
involved in keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17182622 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
16308352 MGI
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
11880192 MGI
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
11273653 MGI
involved in response to wounding IDA
IDA: Inferred from direct assay
10196465 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
16537644 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17761692 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
9556608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kallikrein-8

  • Brain Serine protease 1

  • protease, serine, 19 (neuropsin)

Recombinant Klk8 Proteins

Cat. No. Product Name Accession Purity
HY-P71832 Kallikrein-8 Protein, Mouse (P.pastoris, His) Q61955 (I33-D260) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor 99.53% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klk8 NCBI NCBI:11202