2. Gene
  3. TBC1D10B - TBC1 domain family member 10B Gene

TBC1D10B - TBC1 domain family member 10B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EPI64B; FP2461

Gene ID: 26000 | Gene type: protein coding

About TBC1D10B

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,357,102-30,370,494 (from NCBI)

This gene has 7 transcripts (splice variants), 190 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 19.6), brain (RPKM 12.7) and 25 other tissues.

Summary

Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]

TBC1D10B Products(1)

mRNA Protein Name
NM_015527.4 NP_056342.3 TBC1 domain family member 10B

TBC1D10B Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (364 - 561)

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  • 808 a.a.
Protein Preferred Names Protein Names

TBC1 domain family member 10B

Rab27A-GAPbeta

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14231 TBC1D10B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TBC1D10B MGD MGI:1915699
Macaca mulatta TBC1D10B VGNC VGNC:78202
Bos taurus TBC1D10B VGNC VGNC:35624
Felis catus TBC1D10B VGNC VGNC:65970
Rattus norvegicus TBC1D10B RGD RGD:1309191