TBC1D10B - TBC1 domain family member 10B Gene

Also Known as EPI64B; FP2461

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26000

About TBC1D10B

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,357,102-30,370,494 (from NCBI)

This gene has 7 transcripts (splice variants), 190 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 19.6), brain (RPKM 12.7) and 25 other tissues.

Summary

Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]

TBC1D10B Products (1)

mRNA Protein Name
NM_015527.4 NP_056342.3 TBC1 domain family member 10B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
19077034 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22354992 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
19077034 GOA
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
17562788 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D10B Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (364 - 561)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

TBC1 domain family member 10B

  • Rab27A-GAPbeta

TBC1D10B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TBC1D10B Q4KMP7 CCDC70 Homo sapiens Q6NSX1
Y2H Prey Pooling
32296183
Intra
TBC1D10B Q4KMP7 CCDC70 Homo sapiens Q6NSX1
Validated Y2H
32296183
Intra
TBC1D10B Q4KMP7 CCDC70 Homo sapiens Q6NSX1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14231 TBC1D10B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TBC1D10B MGD MGI:1915699
Macaca mulatta TBC1D10B VGNC VGNC:78202
Bos taurus TBC1D10B VGNC VGNC:35624
Felis catus TBC1D10B VGNC VGNC:65970
Rattus norvegicus TBC1D10B RGD RGD:1309191
Others TBC1D10B NCBI