Fkbp4 - FKBP prolyl isomerase 4 Gene

Also Known as p59; FKBP-4; FKBP-52

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 260321

Summary

Enables copper-dependent protein binding activity and Tau Protein binding activity. Involved in copper ion transport and negative regulation of microtubule polymerization. Located in several cellular components, including axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp4 Products (1)

mRNA Protein Name
NM_001191863.1 NP_001178792.1 peptidyl-prolyl cis-trans isomerase FKBP4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper-dependent protein binding IPI
IPI: Inferred from physical interaction
15133031 RGD
enables tau protein binding IPI
IPI: Inferred from physical interaction
20133804 RGD
Biological Process GO Annotation Evidence References Source
involved in copper ion transport IMP
IMP: Inferred from mutant phenotype
15133031 RGD
involved in negative regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
17435176 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
20133804 RGD
located in cytosol IDA
IDA: Inferred from direct assay
20133804 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20796173 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20796173 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20796173 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP4

  • 52 kDa FK506-binding protein

  • 52 kDa FKBP

  • 59 kDa immunophilin

  • FK506 binding protein 52

  • FK506-binding protein 4

  • FKBP52 protein

  • FKBP59

  • HBI

  • HSP-binding immunophilin

  • PPIase FKBP4

  • immunophilin FKBP52

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04964 FKBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18819 Fkbp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25309 Fkbp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp4 NCBI NCBI:2288