Map2k1 - mitogen-activated protein kinase kinase 1 Gene

Also Known as Mek1; MEKK1; MAPKK1; Prkmk1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26395

About Map2k1

Chromosome 9: 64,093,052-64,160,913 reverse strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 22 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 5.3), cortex adult (RPKM 32.1) and 27 other tissues.

Summary

Enables MAP kinase kinase activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and neurogenesis. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 Products (2)

mRNA Protein Name
NM_008927.5 NP_032953.1 dual specificity mitogen-activated protein kinase kinase 1 isoform 1
NM_001410474.1 NP_001397403.1 dual specificity mitogen-activated protein kinase kinase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
1411546 MGI
enables MAP kinase kinase activity IMP
IMP: Inferred from mutant phenotype
11841548 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10523642 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
23283332 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Bergmann glial cell differentiation IGI
IGI: Inferred from genetic interaction
24431450 MGI
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
24493648 MGI
acts upstream of or within ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
25100655 MGI
involved in MAPK cascade IGI
IGI: Inferred from genetic interaction
21220101 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
24493648 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
10209122 MGI
acts upstream of or within cerebellar cortex formation IGI
IGI: Inferred from genetic interaction
24431450 MGI
acts upstream of endodermal cell differentiation IDA
IDA: Inferred from direct assay
16908534 MGI
acts upstream of or within epithelial cell proliferation involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
25100655 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
18952847 MGI
involved in insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21699731 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
11841548 MGI
acts upstream of or within labyrinthine layer development IMP
IMP: Inferred from mutant phenotype
10209122 MGI
acts upstream of or within lung morphogenesis IGI
IGI: Inferred from genetic interaction
25100655 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
15145949 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: Inferred from mutant phenotype
10209122 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15896720 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within positive regulation of endodermal cell differentiation IDA
IDA: Inferred from direct assay
16908534 MGI
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
19047410 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15896720 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within trachea formation IGI
IGI: Inferred from genetic interaction
25100655 MGI
acts upstream of positive effect type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18202127 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k1 Protein Structure

PKc_MEK1

PKc_MEK1: cd06650 (61 - 379)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 1

  • ERK activator kinase 1

  • MAP kinase kinase 1

  • MAPK/ERK kinase 1

  • protein kinase, mitogen activated, kinase 1, p45

Recombinant Map2k1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73825 MEK1 Protein, Mouse (Inactive, sf9, His-GST) P31938 (M1-I393) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70842 MAP2K1 L115P Recombinant Human Active Protein Kinase / Unkown
HY-E70843 MAP2K1 P124L Recombinant Human Active Protein Kinase / Unkown
HY-RS08033 MAP2K1 Human Pre-designed siRNA Set A / Unkown
HY-RS08034 Map2k1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08035 Map2k1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k1 NCBI NCBI:5604