Slc27a1 - solute carrier family 27 (fatty acid transporter), member 1 Gene

Also Known as Fatp; FATP1; Vlc27a1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26457

Summary

Enables fatty acid Ligase activity; fatty acid transmembrane transporter activity; and identical protein binding activity. Involved in glucose import in response to Insulin stimulus; long-chain fatty acid import into cell; and positive regulation of triglyceride biosynthetic process. Acts upstream of or within several processes, including adiponectin-activated signaling pathway; lipid transport; and positive regulation of protein serine/threonine kinase activity. Located in basal plasma membrane and endoplasmic reticulum. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; phalanx; and sensory organ. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc27a1 Products (8)

mRNA	Protein	Name
NM_001357180.1	NP_001344109.1	long-chain fatty acid transport protein 1
NM_001357181.1	NP_001344110.1	long-chain fatty acid transport protein 1
NM_001357182.1	NP_001344111.1	long-chain fatty acid transport protein 1
NM_011977.4	NP_036107.1	long-chain fatty acid transport protein 1
NM_001357180.1	NP_001344109.1	long-chain fatty acid transport protein 1
NM_001357181.1	NP_001344110.1	long-chain fatty acid transport protein 1
NM_001357182.1	NP_001344111.1	long-chain fatty acid transport protein 1
NM_011977.4	NP_036107.1	long-chain fatty acid transport protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	7954810	MGI
enables fatty acid transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	18258213	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12566451	MGI
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	12235169	MGI
enables oleoyl-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	23024797	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28178239	MGI
enables protein serine/threonine kinase activator activity	IGI IGI: Inferred from genetic interaction	20667975	MGI
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	19560442	MGI
enables very long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	18258213	MGI
enables very long-chain fatty acid-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	10593920	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adiponectin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	20667975	MGI
acts upstream of or within fatty acid transport	IDA IDA: Inferred from direct assay	9671728	MGI
acts upstream of or within fatty acid transport	IMP IMP: Inferred from mutant phenotype	17130465	MGI
involved in glucose import in response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	23024797	MGI
involved in long-chain fatty acid import into cell	IDA IDA: Inferred from direct assay	7954810	MGI
involved in long-chain fatty acid import into cell	IMP IMP: Inferred from mutant phenotype	23024797	MGI
acts upstream of or within long-chain fatty acid transport	IMP IMP: Inferred from mutant phenotype	16611988	MGI
acts upstream of or within medium-chain fatty acid transport	IGI IGI: Inferred from genetic interaction	18258213	MGI
acts upstream of or within positive regulation of heat generation	IMP IMP: Inferred from mutant phenotype	17130465	MGI
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	12235169	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	17130465	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	14991074	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	28035674	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15496455	MGI
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23024797	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	7954810	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
long-chain fatty acid transport protein 1	arachidonate--CoA ligase fatty acid transport protein 1 long-chain-fatty-acid--CoA ligase very long-chain acyl-CoA synthetase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16240	Slc27a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13144	SLC27A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27156	Slc27a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc27a1	NCBI	NCBI:376497