Slc27a4 - solute carrier family 27 (fatty acid transporter), member 4 Gene

Also Known as FATP4; ACSVL4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26569

Summary

Enables oleoyl-CoA Ligase activity and very long-chain fatty acid-CoA Ligase activity. Involved in glucose import in response to Insulin stimulus; long-chain fatty acid import into cell; and negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Acts upstream of or within fatty acid metabolic process; lipid transport; and skin development. Located in brush border membrane; endoplasmic reticulum; and microvillus. Is expressed in several structures, including alimentary system; eye; liver; nervous system; and urinary system. Used to study lethal restrictive dermopathy. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc27a4 Products (1)

mRNA Protein Name
NM_011989.5 NP_036119.1 long-chain fatty acid transport protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
11404000 MGI
enables oleoyl-CoA ligase activity IDA
IDA: Inferred from direct assay
21750264 MGI
enables oleoyl-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
23024797 MGI
enables very long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
15653672 MGI
enables very long-chain fatty acid-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
15653672 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10518211 MGI
acts upstream of or within fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
18843142 MGI
involved in glucose import in response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
23024797 MGI
involved in long-chain fatty acid import into cell IDA
IDA: Inferred from direct assay
21750264 MGI
involved in long-chain fatty acid import into cell IMP
IMP: Inferred from mutant phenotype
23024797 MGI
acts upstream of or within long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
11404000 MGI
acts upstream of or within long-chain fatty acid transport IMP
IMP: Inferred from mutant phenotype
10518211 MGI
acts upstream of or within medium-chain fatty acid transport IDA
IDA: Inferred from direct assay
17062637 MGI
acts upstream of or within medium-chain fatty acid transport IGI
IGI: Inferred from genetic interaction
18258213 MGI
involved in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IDA
IDA: Inferred from direct assay
23407971 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
12821645 MGI
acts upstream of or within very long-chain fatty acid catabolic process IDA
IDA: Inferred from direct assay
17522045 MGI
acts upstream of or within very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
15653672 MGI
acts upstream of or within very long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
17401141 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
14512415 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15496455 MGI
located in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
23024797 MGI
located in microvillus IDA
IDA: Inferred from direct assay
10518211 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15496455 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 4

  • arachidonate--CoA ligase

  • long-chain-fatty-acid--CoA ligase

  • very long-chain acyl-CoA synthetase 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13147 SLC27A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18726 Slc27a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25213 Slc27a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc27a4 NCBI NCBI:10999