PCOLCE2 - procollagen C-endopeptidase enhancer 2 Gene

Also Known as PCPE2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26577

About PCOLCE2

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:142,817,874-142,889,083 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 35 paralogues. Biased expression in fat (RPKM 75.7), heart (RPKM 31.8) and 9 other tissues.

Summary

Enables Collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to be involved in positive regulation of peptidase activity. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PCOLCE2 Products (1)

mRNA Protein Name
NM_013363.4 NP_037495.1 procollagen C-endopeptidase enhancer 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
12393877 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
12393877 GOA
enables peptidase activator activity IDA
IDA: Inferred from direct assay
12393877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCOLCE2 Protein Structure

CUB

CUB: CUB domain (33 - 141)

CUB

CUB: CUB domain (154 - 263)

NTR

NTR: UNC-6/NTR/C345C module (310 - 410)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

procollagen C-endopeptidase enhancer 2

  • procollagen C-proteinase enhancer 2

PCOLCE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCOLCE2 Q9UKZ9 ZWINT Homo sapiens O95229
Anti Tag CoIP
28514442
Intra
PCOLCE2 Q9UKZ9 ZWINT Homo sapiens O95229
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pulmonary Subvalvular Stenosis

  • Pulmonary Infundibular Stenosis

  • Congenital Infundibular Stenosis

  • Infundibular Pulmonic Stenosis

  • Infundibular Pulmonic Stenosis, Congenital

  • Subvalvular Pulmonic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10166 PCOLCE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21248 Pcolce2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27765 Pcolce2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PCOLCE2 VGNC VGNC:32643
Rattus norvegicus PCOLCE2 RGD RGD:1595195
Felis catus PCOLCE2 VGNC VGNC:68730
Macaca mulatta PCOLCE2 VGNC VGNC:75783
Mus musculus PCOLCE2 MGD MGI:1923727
Canis familiaris PCOLCE2 VGNC VGNC:44317
Others PCOLCE2 NCBI