RPS6KC1 - ribosomal protein S6 kinase C1 Gene

Also Known as RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26750

About RPS6KC1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,051,241-213,862,735 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues.

Summary

Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]

RPS6KC1 Products (31)

mRNA	Protein	Name
NM_001136138.4	NP_001129610.1	ribosomal protein S6 kinase delta-1 isoform b
NM_001287218.3	NP_001274147.1	ribosomal protein S6 kinase delta-1 isoform c
NM_001287219.3	NP_001274148.1	ribosomal protein S6 kinase delta-1 isoform c
NM_001287220.3	NP_001274149.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001287221.3	NP_001274150.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349646.2	NP_001336575.1	ribosomal protein S6 kinase delta-1 isoform f
NM_001349647.2	NP_001336576.1	ribosomal protein S6 kinase delta-1 isoform g
NM_001349648.2	NP_001336577.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349649.2	NP_001336578.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349650.2	NP_001336579.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349651.2	NP_001336580.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349652.2	NP_001336581.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349653.2	NP_001336582.1	ribosomal protein S6 kinase delta-1 isoform e
NM_001349654.2	NP_001336583.1	ribosomal protein S6 kinase delta-1 isoform c
NM_001349657.2	NP_001336586.1	ribosomal protein S6 kinase delta-1 isoform h
NM_001349658.2	NP_001336587.1	ribosomal protein S6 kinase delta-1 isoform h
NM_001349659.2	NP_001336588.1	ribosomal protein S6 kinase delta-1 isoform i
NM_001349660.2	NP_001336589.1	ribosomal protein S6 kinase delta-1 isoform i
NM_001349661.2	NP_001336590.1	ribosomal protein S6 kinase delta-1 isoform i
NM_001349662.2	NP_001336591.1	ribosomal protein S6 kinase delta-1 isoform i
NM_001349663.2	NP_001336592.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349664.2	NP_001336593.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349665.2	NP_001336594.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349666.2	NP_001336595.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349667.2	NP_001336596.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349668.2	NP_001336597.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349669.2	NP_001336598.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349670.2	NP_001336599.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349671.2	NP_001336600.1	ribosomal protein S6 kinase delta-1 isoform d
NM_001349672.2	NP_001336601.1	ribosomal protein S6 kinase delta-1 isoform j
NM_012424.6	NP_036556.2	ribosomal protein S6 kinase delta-1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15750338	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	15750338	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KC1 Protein Structure

PX

MIT

Pkinase

0
200
400
600
800
1000
1066 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase delta-1	52 kDa ribosomal protein S6 kinase

RPS6KC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS6KC1	Q96S38	VDR	Homo sapiens	P11473-2	Y2H Prey Pooling	32296183
Intra	RPS6KC1	Q96S38	VDR	Homo sapiens	P11473-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Periventricular Leukomalacia	Leukomalacia, Periventricular Pvl Leukomalacia Periventricular
Hypotonia
Charcot-Marie-Tooth Disease, Axonal, Type 2n	Charcot-Marie-Tooth Disease Axonal Type 2n CMT2N Autosomal Dominant Charcot-Marie-Tooth Disease Type 2n Charcot-Marie-Tooth Neuropathy Axonal Type 2n Charcot-Marie-Tooth Neuropathy, Axonal, Type 2n Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2n Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2n Charcot-Marie-Tooth Disease 2n Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2n Charcot-Marie-Tooth Disease, Type 2n

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08132	Mapkapk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12268	RPS6KC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS6KC1	MGD	MGI:2443419
Rattus norvegicus	RPS6KC1	RGD	RGD:1306578
Macaca mulatta	RPS6KC1	VGNC	VGNC:76935
Canis familiaris	RPS6KC1	VGNC	VGNC:45746
Felis catus	RPS6KC1	VGNC	VGNC:97613
Bos taurus	RPS6KC1	VGNC	VGNC:34148
Others	RPS6KC1	NCBI