Acvr1c - activin A receptor, type IC Gene

Also Known as ALK7; Alk-7; ACTR-IC; ACVRLK7; C230097P10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269275

About Acvr1c

Chromosome 2: 58,157,465-58,247,907 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 6 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 3.9), genital fat pad adult (RPKM 2.9) and 8 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; BMP Receptor binding activity; and activin binding activity. Acts upstream of or within several processes, including negative regulation of Insulin secretion; response to glucose; and response to Insulin. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Orthologous to human ACVR1C (Activin A receptor type 1C). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1c Products (2)

mRNA Protein Name
NM_001111030.1 NP_001104500.1 activin receptor type-1C isoform 1 precursor
NM_001033369.3 NP_001028541.1 activin receptor type-1C isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
15485907 MGI
NOT acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15485907 MGI
acts upstream of insulin secretion IMP
IMP: Inferred from mutant phenotype
18480258 MGI
acts upstream of or within lipid storage IMP
IMP: Inferred from mutant phenotype
18480258 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18480258 MGI
acts upstream of or within response to dietary excess IMP
IMP: Inferred from mutant phenotype
18480259 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
18480258 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
18480259 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr1c Protein Structure

Activin_recp

Activin_recp: pfam01064 (26 - 94)

TGF_beta_GS

TGF_beta_GS: pfam08515 (165 - 192)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (198 - 485)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

activin receptor type-1C

  • activin receptor type IC

  • activin receptor-like kinase 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174784 Human ACVR1C mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr1c NCBI NCBI:130399