Idh2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial Gene

Also Known as IDPm; Idh-2; E430004F23

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269951

About Idh2

Chromosome 7: 79,744,594-79,765,140 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 261 orthologues, 1 paralogue and is associated with 9 phenotypes. Broad expression in heart adult (RPKM 329.1), kidney adult (RPKM 134.6) and 22 other tissues.

Summary

Enables isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in several processes, including NADP biosynthetic process; isocitrate metabolic process; and negative regulation of matrix metallopeptidase secretion. Predicted to act upstream of or within glyoxylate cycle and tricarboxylic acid cycle. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung Cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Apr 2022]

Idh2 Products (1)

mRNA Protein Name
NM_173011.2 NP_766599.2 isocitrate dehydrogenase [NADP], mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables isocitrate dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
7323947 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18275837 MGI
located in peroxisome IDA
IDA: Inferred from direct assay
18275837 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Idh2 Protein Structure

PTZ00435

PTZ00435: PTZ00435 (38 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

isocitrate dehydrogenase [NADP], mitochondrial

  • ICD-M

  • IDH

  • IDP

  • NADP(+)-specific ICDH

  • NADP+-specific isocitrate dehydrogenase

  • oxalosuccinate decarboxylase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104042 Vorasidenib Inhibitor 99.76% Yes
HY-18690 Enasidenib Inhibitor 99.93% Yes
HY-18690A Enasidenib mesylate Inhibitor 99.68% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-131312 Crelosidenib Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15734 AGI-6780 Inhibitor 99.26% Unkown
HY-164542 TQ05310 Inhibitor / Unkown
HY-149359 IHMT-IDH1-053 Inhibitor / Unkown
HY-145743 CP-17 Inhibitor / Unkown
HY-120765 BRD2879 Inhibitor / Unkown
HY-131312A Crelosidenib gentisate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Idh2 NCBI NCBI:3418