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Nlrx1 - NLR family member X1 Gene

Also Known as NOD9

Species: Mus musculus

Gene Type: protein coding

Gene ID: 270151

About Nlrx1

Chromosome 9: 44,164,014-44,179,896 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 193 orthologues, 22 paralogues and is associated with 13 phenotypes. Ubiquitous expression in colon adult (RPKM 11.8), adrenal adult (RPKM 1.3) and 27 other tissues.

Summary

Predicted to enable ATP binding activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of cytokine production; and negative regulation of defense response. Located in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrx1 Products (3)

mRNA	Protein	Name
NM_178420.3	NP_848507.2	NLR family member X1
NM_001163742.1	NP_001157214.1	NLR family member X1
NM_001163743.1	NP_001157215.1	NLR family member X1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21703540	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of interferon-beta production	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21703540	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	21703540	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nlrx1 Protein Structure

P-loop_NTPase

LRR_RI

PPP1R42

LRR_RI

0
200
400
600
800
975 a.a.

Protein Preferred Names	Protein Names
NLR family member X1	nucleotide-binding domain and leucine-rich repeat containing

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Phase
HY-141521	Amelenodor	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-CE00479	(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA	Modulator	/	Unkown
HY-RS09365	NLRX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09366	Nlrx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09367	Nlrx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148285	Succinyl CoA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrx1	NCBI	NCBI:79671