LAMP3 - lysosomal associated membrane protein 3 Gene

Also Known as LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27074

About LAMP3

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,122,215-183,163,813 (from NCBI)

This gene has 5 transcripts (splice variants) and 50 orthologues. Biased expression in lung (RPKM 74.1), appendix (RPKM 11.0) and 3 other tissues.

Summary

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

LAMP3 Products (1)

mRNA Protein Name
NM_014398.4 NP_055213.2 lysosome-associated membrane glycoprotein 3 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
25681212 GOA
involved in negative regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25681212 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23651994 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25681212 GOA
involved in regulation of viral life cycle IMP
IMP: Inferred from mutant phenotype
21810281 GOA
involved in response to interferon-alpha IMP
IMP: Inferred from mutant phenotype
23651994 GOA
NOT involved in symbiont entry into host cell IMP
IMP: Inferred from mutant phenotype
21810281 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
21810281 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
25681212 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21810281 GOA
located in vesicle IDA
IDA: Inferred from direct assay
25681212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAMP3 Protein Structure

Lamp

Lamp: Lysosome-associated membrane glycoprotein (Lamp) (120 - 416)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

lysosome-associated membrane glycoprotein 3

  • DC-lysosome-associated membrane glycoprotein

Recombinant LAMP3 Proteins

Cat. No. Product Name Accession Purity
HY-P77435 LAMP3/CD208 Protein, Human (HEK293, His) Q9UQV4/NP_055213.2 (K28-T381) ≥ 95%, as determined by reducing SDS-PAGE.

LAMP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811173 CD208 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Mumps

  • Parotitis Due To Mumps Virus

  • Mumps Nos

  • Epidemic Parotitis

  • Infectious Parotitis
Rem Sleep Behavior Disorder

  • Rapid Eye Movement Sleep Behavior Disorder

  • Rem Sleep Behaviour Disorder

  • Rapid Eye Movement Sleep Behaviour Disorder

  • Rem - [Rapid Eye Movement] Behaviour Disorder
Gaucher'S Disease

  • Gaucher Disease

  • Kerasin Thesaurismosis

  • Glucocerebrosidase Deficiency

  • Glucosylceramidase Deficiency

  • Cerebroside Lipidosis Syndrome

  • Acid Beta-Glucosidase Deficiency

  • Glucosylceramide Beta-Glucosidase Deficiency

  • Acute Cerebral Gaucher Disease

  • Gaucher Splenomegaly

  • Glucocerebrosidosis

  • Glucosyl Cerebroside Lipidosis

  • Kerasin Lipoidosis

  • Lipoid Histiocytosis

  • Glocucerebrosidase Deficiency

  • Sphingolipidosis 1

  • Gaucher Syndrome

  • Gauchers Disease

  • Gd

  • Glucosylceramide Lipidosis

  • Kerasin Histiocytosis

  • Gaucher Disease, Type 1

  • Gaucher Disease, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07511 LAMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17768 Lamp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24235 Lamp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LAMP3 VGNC VGNC:30777
Rattus norvegicus LAMP3 RGD RGD:1307928
Felis catus LAMP3 VGNC VGNC:63187
Macaca mulatta LAMP3 VGNC VGNC:74045
Mus musculus LAMP3 MGD MGI:2441659
Others LAMP3 NCBI