MCAT - malonyl-CoA-acyl carrier protein transacylase Gene

Homo sapiens

Also known as MT; MCT; MCT1; fabD; NET62; FASN2C

Gene ID: 27349 | Gene type: protein coding

About MCAT

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,132,206-43,143,398 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 9.6), testis (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

MCAT Products(2)

mRNA	Protein	Name
NM_014507.3	NP_055322.1	malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor
NM_173467.5	NP_775738.3	malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor

MCAT Protein Structure

Acyl_transf_1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

malonyl-CoA-acyl carrier protein transacylase, mitochondrial

[Acyl-carrier-protein] malonyltransferase

Related Diseases

Diseases

Alias

Autosomal Recessive Isolated Optic Atrophy

Autosomal Recessive Non-Syndromic Optic Atrophy

Optic Atrophy 6

OPA6	Optic Atrophy, Congenital Or Early Infantile, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15533	LY 3000328	Inhibitor	98.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08216	MCAT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCAT	VGNC	VGNC:43069
Felis catus	MCAT	VGNC	VGNC:63410
Macaca mulatta	MCAT	VGNC	VGNC:74616
Mus musculus	MCAT	MGD	MGI:2388651
Rattus norvegicus	MCAT	RGD	RGD:1306698
Bos taurus	MCAT	VGNC	VGNC:31297

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