Abcc5 - ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Gene

Also Known as Mrp5; Abcc5a; Abcc5b; 2900011L11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27416

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine Anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Abcc5 Products (2)

mRNA Protein Name
NM_013790.2 NP_038818.2 ATP-binding cassette sub-family C member 5 isoform 1
NM_176839.1 NP_789809.1 ATP-binding cassette sub-family C member 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ABC-type transporter activity IMP
IMP: Inferred from mutant phenotype
17540771 MGI
enables carbohydrate derivative transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17540771 MGI
enables macromolecule transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17540771 MGI
Biological Process GO Annotation Evidence References Source
involved in hyaluronan biosynthetic process IMP
IMP: Inferred from mutant phenotype
17540771 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16361063 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
24836561 MGI
is active in plasma membrane IMP
IMP: Inferred from mutant phenotype
17540771 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 5

multidrug resistance-associated protein 5

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5a

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5b

  • ATP-binding cassette, sub-family C, member 5

  • MOAT-C

  • SMRP

  • multi-specific organic anion transporter C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00064 ABCC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20844 Abcc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27358 Abcc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc5 NCBI NCBI:10057