AMY1A - amylase alpha 1A Gene

Also Known as AMY1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 276

About AMY1A

Cytogenetic location: 1p21.1 Genomic coordinates (GRCh38): 1:103,655,519-103,664,554 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 7 paralogues. Restricted expression toward salivary gland (RPKM 4834.2).

Summary

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and Polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AMY1A Products (2)

mRNA	Protein	Name
NM_001008221.1	NP_001008222.1	alpha-amylase 1A precursor
NM_004038.4	NP_004029.2	alpha-amylase 1A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-amylase activity	IDA IDA: Inferred from direct assay	12527308	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	12527308	GOA
enables chloride ion binding	IDA IDA: Inferred from direct assay	12527308	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in oligosaccharide metabolic process	IDA IDA: Inferred from direct assay	12527308	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15299664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMY1A Protein Structure

Alpha-amylase

Alpha-amylase_C

0
100
200
300
400
511 a.a.

Protein Preferred Names	Protein Names
alpha-amylase 1A	1,4-alpha-D-glucan glucanohydrolase 1

AMY1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82813	Salivary alpha Amylase Antibody (YA2558)	WB	Human
HY-P84042	Salivary alpha Amylase Antibody (YA3739)	WB, FC, ELISA	Human, Rat
HY-P84042A	Salivary alpha Amylase Antibody (YA3739)(PBS only)	WB, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Alveolar Periostitis	Dry Socket Alveolitis Of Jaw Dry Tooth Socket Alveolar Pyorrhea Alveolar Osteitis Alveolitis Sicca Dolorosa Alveolodental Periostitis
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Sick Building Syndrome
Avoidant Personality Disorder	Anxious Personality Disorder Personality Disorders
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00672	AMY1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown