Adamts13 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 Gene

Also Known as Gm710; vWF-CP; ADAM-TS13; ADAMTS-13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 279028

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]

Adamts13 Products (4)

mRNA Protein Name
NM_001001322.2 NP_001001322.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein
NM_001290463.1 NP_001277392.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 2 precursor
NM_001290464.1 NP_001277393.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform IAP-a precursor
NM_001290465.1 NP_001277394.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform IAP-b precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
16200209 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 13

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13

  • vWF-CP mRNA for von Willebrand factor-cleaving

  • vWF-cleaving protease

  • von Willebrand factor-cleaving protease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5354 FRETS-VWF73 97.30% Unkown
HY-P5354A FRETS-VWF73 TFA 97.44% Unkown
HY-RS00294 ADAMTS13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17864 Adamts13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24333 Adamts13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts13 NCBI NCBI:11093