GPR12 - G protein-coupled receptor 12 Gene

Also Known as GPCR12; GPCR21; PPP1R84

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2835

About GPR12

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,755,200-26,760,786 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 18 paralogues. Biased expression in brain (RPKM 3.0) and salivary gland (RPKM 0.6).

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR12 Products (1)

mRNA Protein Name
NM_005288.4 NP_005279.1 G-protein coupled receptor 12

GPR12 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (61 - 301)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 12

  • protein phosphatase 1, regulatory subunit 84

Related Diseases

Diseases Alias
Vulvar Dystrophy

  • Dystrophy Of Vulva
Lennox-Gastaut Syndrome

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-108496 Sphingosine-1-phosphate Agonist 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108496S Sphingosine-1-phosphate-d7 Agonist 99.9% Unkown
HY-183657A GPR3 inverse agonist-1 TFA / Unkown
HY-RS05655 GPR12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-167754 Resolvin D5 n-3 DPA Agonist / Unkown
HY-RS20031 Gpr12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26534 Gpr12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR12 VGNC VGNC:41395
Felis catus GPR12 VGNC VGNC:67414
Macaca mulatta GPR12 VGNC VGNC:106264
Rattus norvegicus GPR12 RGD RGD:68333
Mus musculus GPR12 MGD MGI:101909
Bos taurus GPR12 VGNC VGNC:29547
Others GPR12 NCBI